Department of Hematology, TMG Asaka Medical Center, Japan.
Division of Hematology, Department of Internal Medicine, National Defense Medical College, Japan.
Intern Med. 2022 May 15;61(10):1581-1585. doi: 10.2169/internalmedicine.9177-21. Epub 2022 Mar 19.
We herein report two cases of coronavirus disease 2019 (COVID-19) vaccine-induced immune thrombocytopenia (ITP). A 69-year-old Japanese man developed severe thrombocytopenia after COVID-19 vaccination. He had oral bleeding and hemoptysis but no thrombotic symptoms. He improved rapidly with oral prednisolone therapy. A 34-year-old Japanese woman had generalized purpura after COVID-19 vaccination. Her platelet count improved rapidly after treatment with prednisolone and eltrombopag. The occurrence of two cases of ITP after COVID-19 vaccination at a single institution suggests that there could be more such undiagnosed cases, especially cases of mild secondary ITP.
我们在此报告两例由 2019 年冠状病毒病（COVID-19）疫苗引起的免疫性血小板减少症（ITP）。一名 69 岁的日本男性在 COVID-19 疫苗接种后发生严重血小板减少症。他有口腔出血和咯血，但没有血栓形成症状。他在口服泼尼松龙治疗后迅速改善。一名 34 岁的日本女性在 COVID-19 疫苗接种后出现全身紫癜。她的血小板计数在泼尼松龙和艾曲波帕治疗后迅速改善。在一家医疗机构中发生两例 ITP 病例表明，可能有更多此类未确诊的病例，尤其是轻度继发性 ITP 病例。
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