代谢的中央调控器。
The central moTOR of metabolism.
机构信息
Department of Biochemistry, University of Wisconsin-Madison, Madison, WI, USA.
William S. Middleton Memorial Veterans Hospital, Madison, WI, USA; Department of Medicine, University of Wisconsin-Madison, Madison, WI, USA.
出版信息
Dev Cell. 2022 Mar 28;57(6):691-706. doi: 10.1016/j.devcel.2022.02.024. Epub 2022 Mar 21.
Abstract
The protein kinase mechanistic target of rapamycin (mTOR) functions as a central regulator of metabolism, integrating diverse nutritional and hormonal cues to control anabolic processes, organismal physiology, and even aging. This review discusses the current state of knowledge regarding the regulation of mTOR signaling and the metabolic regulation of the four macromolecular building blocks of the cell: carbohydrate, nucleic acid, lipid, and protein by mTOR. We review the role of mTOR in the control of organismal physiology and aging through its action in key tissues and discuss the potential for clinical translation of mTOR inhibition for the treatment and prevention of diseases of aging.
摘要
蛋白激酶雷帕霉素靶蛋白（mTOR）作为代谢的中央调节因子，整合了多种营养和激素信号，以控制合成代谢过程、机体生理学甚至衰老。本文讨论了目前关于 mTOR 信号转导的调节以及 mTOR 对细胞的四大高分子构建块（碳水化合物、核酸、脂质和蛋白质）的代谢调节的认识。我们通过 mTOR 在关键组织中的作用来回顾 mTOR 在控制机体生理学和衰老中的作用，并讨论了抑制 mTOR 用于治疗和预防衰老相关疾病的临床转化的潜力。
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