Kumar Manoj, Dheeraj Dheeraj, Kant Ravi, Kumar Ashok
Medicine, Uttar Pradesh University of Medical Sciences, Saifai, IND.
General Medicine, All India Institute of Medical Sciences, Rishikesh, Rishikesh, IND.
Cureus. 2022 Feb 17;14(2):e22317. doi: 10.7759/cureus.22317. eCollection 2022 Feb.
Objective In this study, we aimed to determine the association between anti-thyroid peroxidase (anti-TPO) antibody and dyslipidemia in subclinical hypothyroidism (SCH). Materials and methods We conducted a cross-sectional case-control study in the department of medicine at a tertiary care teaching hospital in central India. The study consisted of 150 patients (75 cases and 75 controls) who fulfilled the inclusion and exclusion criteria. Results The study showed that serum cholesterol was high in 23.1% of cases in the negative anti-TPO antibody SCH sub-group and 88.7% of cases in the positive anti-TPO antibody SCH sub-group (p<0.001). Serum triglyceride (TG) levels were high in 61.5% of cases in the negative anti-TPO antibody SCH sub-group and 90.3% of cases in the positive anti-TPO antibody SCH sub-group (p=0.008). Serum high-density lipoproteins (HDL) were low in 15.4% of cases in the negative anti-TPO antibody SCH sub-group and 24.2% of cases in the positive anti-TPO antibody SCH sub-group (p=0.490). Serum low-density lipoproteins (LDL) were high in 61.5% of cases in the negative anti-TPO antibody SCH sub-group and 90.3% of cases in the positive anti-TPO antibody SCH sub-group (p=0.008). Serum very-low-density lipoproteins (VLDL) were high in 84.6% of cases in the negative anti-TPO antibody SCH sub-group and 83.9% of cases in the positive anti-TPO antibody SCH sub-group (p=0.947). Based on our findings, 82.8% of participants with negative anti-TPO antibodies had normal serum LDL levels, while 11.1% of participants with positive anti-TPO antibodies had normal LDL levels (p<0.001). The study also showed that elevated serum LDL was present in 17.2% of participants with negative anti-TPO antibody levels and 88.9% of participants with positive anti-TPO antibodies (p<0.001). The study showed a correlation coefficient of 0.0432 between serum TG and anti-TPO antibody levels (p<0.001). Conclusion Our findings showed an increased incidence of dyslipidemia in SCH patients with positive anti-TPO antibodies. SCH with positive anti-TPO antibody is significantly associated with elevated serum total cholesterol (TC) levels, serum TG levels, and serum LDL levels. Hence, early screening and diagnosis of dyslipidemia are crucial to prevent cardiovascular morbidity and mortality in SCH patients with positive anti-TPO antibodies.
目的 在本研究中，我们旨在确定亚临床甲状腺功能减退症（SCH）患者中抗甲状腺过氧化物酶（抗-TPO）抗体与血脂异常之间的关联。材料与方法 我们在印度中部一家三级医疗教学医院的内科进行了一项横断面病例对照研究。该研究纳入了150例符合纳入和排除标准的患者（75例病例和75例对照）。结果 研究表明，抗-TPO抗体阴性的SCH亚组中23.1%的病例血清胆固醇升高，抗-TPO抗体阳性的SCH亚组中88.7%的病例血清胆固醇升高（p<0.001）。抗-TPO抗体阴性的SCH亚组中61.5%的病例血清甘油三酯（TG）水平升高，抗-TPO抗体阳性的SCH亚组中90.3%的病例血清TG水平升高（p=0.008）。抗-TPO抗体阴性的SCH亚组中15.4%的病例血清高密度脂蛋白（HDL）降低，抗-TPO抗体阳性的SCH亚组中24.2%的病例血清HDL降低（p=0.490）。抗-TPO抗体阴性的SCH亚组中61.5%的病例血清低密度脂蛋白（LDL）升高，抗-TPO抗体阳性的SCH亚组中90.3%的病例血清LDL升高（p=0.008）。抗-TPO抗体阴性的SCH亚组中84.6%的病例血清极低密度脂蛋白（VLDL）升高，抗-TPO抗体阳性 的SCH亚组中83.9%的病例血清VLDL升高（p=0.947）。根据我们的研究结果，抗-TPO抗体阴性的参与者中有82.8%的人血清LDL水平正常，而抗-TPO抗体阳性的参与者中有11.1%的人LDL水平正常（p<0.001）。研究还表明抗-TPO抗体水平阴性的参与者中有17.2%的人血清LDL升高，抗-TPO抗体阳性的参与者中有88.9%的人血清LDL升高（p<0.001）。研究显示血清TG与抗-TPO抗体水平之间的相关系数为0.0432（p<0.001）。结论 我们的研究结果表明，抗-TPO抗体阳性的SCH患者血脂异常的发生率增加。抗-TPO抗体阳性的SCH与血清总胆固醇（TC）水平、血清TG水平和血清LDL水平升高显著相关。因此，早期筛查和诊断血脂异常对于预防抗-TPO抗体阳性的SCH患者发生心血管疾病的发病率和死亡率至关重要。
