Dey Anupam, Kanneganti Vineetha, Das Debasish
Department of General Medicine, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India.
Department of Intern, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India.
J Family Med Prim Care. 2019 Jul;8(7):2439-2444. doi: 10.4103/jfmpc.jfmpc_348_19.
Subclinical hypothyroidism is defined as a serum TSH level above the upper limit of normal with normal levels of serum free thyroxine. It is a common thyroid disorder affecting 3-15% of the adult population.
To study the cardiovascular profile of patients with subclinical hypothyroidism, and to establish cardiac risk factors emerging out of subclinical hypothyroidism.
Adult patients attending General Medicine department and diagnosed with subclinical hypothyroidism over a period of 2 months were enrolled. History and general examination was done. Fasting lipid profile, hsCRP, electrocardiography and echocardiography were done.
The mean age was 35.1 (SD = 10.26). Most common age group affected is 20-30 years. There are about 12% of the enrolled patients were overweight (OW), and 24% were obese (OB). 16% had stage 1 hypertension, and 4% had stage 2 hypertension. 92% of the patients had dyslipidemia. 64% patients had raised LDL. 44% of the patients had raised hsCRP levels. 44% patients showed abnormal findings and the most common abnormality was found to be grade 1 left ventricular diastolic dysfunction.
Subclinical hypothyroidism is seen to be associated with a rise in hsCRP independent of other cardiac risk factors. A large number of patients have dyslipidemia which is a significant cardiac risk factor. Early Diagnosis and treatment of subclinical hypothyroidism will have possible cardioprotective advantages.
亚临床甲状腺功能减退症的定义为血清促甲状腺激素（TSH）水平高于正常上限，而血清游离甲状腺素水平正常。它是一种常见的甲状腺疾病，影响3%至15%的成年人口。
研究亚临床甲状腺功能减退症患者的心血管状况，并确定由亚临床甲状腺功能减退症引发的心脏危险因素。
纳入在普通内科就诊且在2个月内被诊断为亚临床甲状腺功能减退症的成年患者。进行了病史采集和全身检查。检测了空腹血脂、高敏C反应蛋白（hsCRP）、心电图和超声心动图。
平均年龄为35.1岁（标准差=10.26）。受影响最常见的年龄组为20至30岁。约12%的入选患者超重，24%为肥胖。16%患有1期高血压，4%患有2期高血压。92%的患者患有血脂异常。64%的患者低密度脂蛋白（LDL）升高。44%的患者hsCRP水平升高。44%的患者有异常发现，最常见的异常是1级左心室舒张功能障碍。
亚临床甲状腺功能减退症被认为与hsCRP升高有关，且独立于其他心脏危险因素。大量患者患有血脂异常，这是一个重要的心脏危险因素。亚临床甲状腺功能减退症的早期诊断和治疗可能具有心脏保护作用。
