Beitz J, Schimke E, Liebaug U, Block H U, Beitz A, Honigmann G, Sziegoleit W, Müller G, Mest H J
Klin Wochenschr. 1986 Sep 1;64(17):793-9. doi: 10.1007/BF01732189.
Ten healthy and twenty diabetic volunteers (type 1) received 15 capsules (à 450 mg) cod liver oil for 2 weeks daily in addition to a "normal" diet. The levels of eicosapentaenoic acid in the plasma phospholipids of both groups were increased after the treatment. The inhibition of the prostacyclin formation by LDL was diminished when the LDL was isolated after the treatment in comparison to LDL taken in the same concentration and from the same donors before it. The thromboxane B2 (TXB2) synthesis capacity of clotting whole blood, thrombin-induced TXB2 formation by platelets as well as the 15(S)-hydroxy-11 alpha,9 alpha-epoxymethano-5Z, 13E-prostadienoic acid-induced platelet aggregation were not altered by the treatment in healthy volunteers, whereas in diabetics the TXB2 formation capacity of clotting whole blood was decreased after the treatment in comparison with before it.
十名健康志愿者和二十名1型糖尿病志愿者除了食用“正常”饮食外，每天还服用15粒（每粒450毫克）鱼肝油胶囊，持续2周。治疗后，两组血浆磷脂中二十碳五烯酸的水平均有所升高。与治疗前从相同供体获取的相同浓度的低密度脂蛋白（LDL）相比，治疗后分离出的LDL对前列环素形成的抑制作用减弱。健康志愿者的凝血全血中血栓素B2（TXB2）的合成能力、血小板凝血酶诱导的TXB2形成以及15（S）-羟基-11α，9α-环氧甲撑-5Z，13E-前列腺二烯酸诱导的血小板聚集不受治疗影响，而在糖尿病患者中，治疗后凝血全血的TXB2形成能力与治疗前相比有所下降。
