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The influence of linseed oil diet on fatty acid pattern in phospholipids and thromboxane formation in platelets in man.

作者信息

Mest H J, Beitz J, Heinroth I, Block H U, Förster W

出版信息

Klin Wochenschr. 1983 Feb 15;61(4):187-91. doi: 10.1007/BF01488973.

DOI:10.1007/BF01488973
PMID:6341702
Abstract

Ten healthy volunteers daily received 30 ml linseed oil for 4 weeks in addition to the "normal" diet. The influence of linseed oil diet on the fatty acid pattern of plasma phospholipids and thromboxane formation in platelets was investigated. The fatty acid pattern was analysed by gas liquid chromatography. The alpha-linolenic, eicosapentaenoic and docosahexaenoic acids were increased (p less than 0.01), whereas linoleic and arachidonic acids were decreased (p less than 0.05) after 4 weeks of the linseed oil diet. The thromboxane formation of platelets were unchanged. Additionally the influence of HDL and LDL on PGI2 biosynthesis in pig aortic microsomes (PAM) was investigated. HDL taken from serum before and after 3 weeks of linseed oil diet and LDL taken after 3 weeks of diet stimulated the PGI2 formation in PAM, whereas LDL taken from serum before the diet period inhibited the PGI2 formation in PAM.

摘要

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Influence of a cod liver oil diet in healthy and insulin-dependent diabetic volunteers on fatty acid pattern, inhibition of prostacyclin formation by low density lipoprotein (LDL) and platelet thromboxane.鱼肝油饮食对健康及胰岛素依赖型糖尿病志愿者脂肪酸模式、低密度脂蛋白（LDL）对前列环素生成的抑制作用及血小板血栓素的影响。
Klin Wochenschr. 1986 Sep 1;64(17):793-9. doi: 10.1007/BF01732189.
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Long-term effects of dietary marine omega-3 fatty acids upon plasma and cellular lipids, platelet function, and eicosanoid formation in humans.膳食海洋ω-3脂肪酸对人体血浆和细胞脂质、血小板功能及类二十烷酸生成的长期影响。
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[Comparison of the effect of linolenic acid and eicosapentaenoic acid on prostaglandin biosynthesis and thrombocyte function in humans].[亚麻酸和二十碳五烯酸对人体前列腺素生物合成及血小板功能影响的比较]
Klin Wochenschr. 1986 Mar 17;64(6):274-80. doi: 10.1007/BF01711937.
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The anti-thrombotic effects of prostacyclin.前列环素的抗血栓形成作用。
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