耐受性益生菌对狼疮患者来源的树突状细胞迁移潜能的抑制作用。
Inhibitory effects of tolerogenic probiotics on migratory potential of lupus patient-derived DCs.
作者信息
Esmaeili Seyed-Alireza, Taheri Ramezan Ali, Mahmoudi Mahmoud, Momtazi-Borojeni Amir Abbas, Morshedi Mehdi, Bahramifar Ali, Fasihi-Ramandi Mahdi
机构信息
Immunology Research Center, Bu-Ali Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran.
Immunology Department, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
出版信息
Iran J Basic Med Sci. 2021 Nov;24(11):1509-1514. doi: 10.22038/IJBMS.2021.58438.12982.
OBJECTIVES
The present study aimed to evaluate whether and treatments can induce regulatory phenotype, together with modulating the expression of chemokine receptors (CRs) in dendritic cells (DCs). The CRs of DCs have been found to be involved in the pathogenesis of Systemic lupus erythematosus (SLE) through directing recruitment and migration of immune cells.
MATERIALS AND METHODS
In brief, monocytes of patients with SLE and healthy donors were isolated and differentiated to regulatory or inflammatory mature DCs through treatment with , , mixed probiotics, and LPS.
RESULTS
FACScan analysis showed that the expression of CRs including CXCR3, CCR5, CCR4, and CCR3, was significantly reduced in all probiotic-treated groups of SLE and healthy (control) donors when compared with the LPS treated group.
CONCLUSION
The results demonstrated that tolerogenic probiotics could prevent or decrease the expression of inflammatory CRs on the surface of tolerogenic DCs during the maturation process.
目的
本研究旨在评估[具体物质]和[具体物质]治疗是否能够诱导调节性表型，同时调节树突状细胞（DCs）中趋化因子受体（CRs）的表达。已发现DCs的CRs通过指导免疫细胞的募集和迁移参与系统性红斑狼疮（SLE）的发病机制。
材料与方法
简而言之，分离SLE患者和健康供体的单核细胞，并通过用[具体物质]、[具体物质]、混合益生菌和脂多糖（LPS）处理，将其分化为调节性或炎性成熟DCs。
结果
流式细胞仪分析显示，与LPS处理组相比，SLE和健康（对照）供体的所有益生菌处理组中，包括CXCR3、CCR5、CCR4和CCR3在内的CRs表达均显著降低。
结论
结果表明，耐受性益生菌在成熟过程中可预防或降低耐受性DCs表面炎性CRs的表达。
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