2-溴丙酰胺对鼠伤寒沙门氏菌的选择性诱变活性。一项构效关系研究。

Selective mutagenic activity of 2-bromo-propanamides on Salmonella typhimurium. A structure-activity study.

作者信息

Dolzani L, Tamaro M, Monti-Bragadin C, Cavicchioni G, Vecchiati G, D'Angeli F

出版信息

Mutat Res. 1986 Oct;172(1):29-36. doi: 10.1016/0165-1218(86)90102-3.

Abstract

Nineteen 2-halogeno-acetamides, -propanamides, and -iso-butyramides and four related epoxyamides were tested as mutagens for Salmonella typhimurium TA100. Mutagenic activity was observed in strictly selected 2-halogenoamides and in all epoxyamides. The effectiveness of 2-halogenoamides depends upon: the character of the carbon carrying the halogen (1 degree, 2 degrees, 3 degrees); the nature of the halogen (Br, Cl); the substitution at nitrogen. Some considerations concerning the selectivity observed are presented.

摘要

对19种2-卤代乙酰胺、-丙酰胺和-异丁酰胺以及4种相关的环氧酰胺作为鼠伤寒沙门氏菌TA100的诱变剂进行了测试。在经过严格筛选的2-卤代酰胺和所有环氧酰胺中均观察到诱变活性。2-卤代酰胺的有效性取决于：携带卤素的碳的性质（伯、仲、叔）；卤素的性质（溴、氯）；氮上的取代情况。并提出了关于所观察到的选择性的一些考虑因素。