Department of Occupational Therapy, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, 50200, Thailand.
Medical Laboratory Techniques Department Al-Maarif University College, Lebanon.
Anal Methods. 2022 Mar 31;14(13):1301-1310. doi: 10.1039/d2ay00111j.
The human epidermal growth factor receptor 2 (HER-2) protein is a member of the epidermal growth factor receptor (EGFR or ErbB) family and is a transmembrane tyrosine kinase receptor. HER-2 is highly regulated in ovarian, lung, gastric, oral, and breast cancers. The low specificity, complexity, expensiveness and the lack of sensitivity are essential restrictions in traditional diagnosis methods such as FISH, immunohistochemistry and PCR and these disadvantages led to the need for more studies on alternative methods. Biosensor technology has greatly affected the quality of human life owing to its features including, sensitivity, specificity, and rapid diagnosis and monitoring of different patient diseases. In this review article, we examine various biosensors, considering that they have been categorized based on the transducers used including piezoelectric biosensors, optical sensors such as fluorescence and surface plasmon resonance, and electrochemical types for the diagnosis of HER-2 and the effectiveness of some drugs against that. Attention to developing some types of biosensor devices such as colorimetric biosensors for HER-2 detection can be an important point in future studies.
人类表皮生长因子受体 2（HER-2）蛋白是表皮生长因子受体（EGFR 或 ErbB）家族的一员，是一种跨膜酪氨酸激酶受体。HER-2 在卵巢癌、肺癌、胃癌、口腔癌和乳腺癌中高度调控。传统诊断方法，如 FISH、免疫组织化学和 PCR 等方法存在特异性低、复杂性高、昂贵和缺乏敏感性等局限性，这导致需要对替代方法进行更多的研究。生物传感器技术具有很高的灵敏度、特异性和快速诊断和监测不同患者疾病的特点，因此极大地影响了人类的生活质量。在这篇综述文章中，我们研究了各种生物传感器，考虑到它们是根据所使用的换能器进行分类的，包括压电生物传感器、光学传感器（如荧光和表面等离子体共振）以及电化学类型，用于诊断 HER-2 和一些针对该受体的药物的有效性。未来的研究中，关注开发用于 HER-2 检测的比色生物传感器等某些类型的生物传感器设备可能是一个重要的研究方向。
