Department of Chemistry, Faculty of Science, University of Abdelmalek Essaadi, B.P. 2121, M'Hannech II, 93002, Tétouan, Morocco.
Department of Civil and Environmental Engineering, Hanyang University, 222 Wangsimni-Ro, Seoul, 04763, South Korea.
Biosens Bioelectron. 2022 Feb 1;197:113767. doi: 10.1016/j.bios.2021.113767. Epub 2021 Nov 3.
Surface plasmon resonance approach is a highly useful option to offer optical and label-free detection of target bioanalytes with numerous advantages (e.g., low-cost fabrication, appreciable sensitivity, label-free detection, and outstanding accuracy). As such, it allows early diagnosis of cancer biomarkers to monitor tumor progression and to prevent the recurrence of oncogenic tumors. This work highlights the recent progress in SPR biosensing technology for the diagnosis of various cancer types (e.g., lung, breast, prostate, and ovarian). Further, the performance of various SPR biosensors is also evaluated in terms of the basic quality assurance criteria (e.g., limit of detection (LOD), selectivity, sensor response time, and reusability). Finally, the limitations and future challenges associated with SPR biosensors are also discussed with respect to cancer biomarker detection.
表面等离子体共振方法是一种非常有用的光学和无标记检测目标生物分析物的选择，具有许多优点（例如，低成本制造、可观的灵敏度、无标记检测和出色的准确性）。因此，它可以早期诊断癌症生物标志物，监测肿瘤的进展，并预防致癌肿瘤的复发。这项工作重点介绍了用于诊断各种癌症类型（例如肺癌、乳腺癌、前列腺癌和卵巢癌）的 SPR 生物传感技术的最新进展。此外，还根据基本质量保证标准（例如检测限 (LOD)、选择性、传感器响应时间和可重复性）评估了各种 SPR 生物传感器的性能。最后，还讨论了与 SPR 生物传感器相关的癌症生物标志物检测的局限性和未来挑战。
