Chen Yuan-Yuei, Chen Wei-Liang, Peng Tao-Chun, Liaw Fang-Yih, Chao Yuan-Ping, Kao Tung-Wei
Department of Pathology, Tri-Service General Hospital and School of Medicine, National Defense Medical Center, Taipei, Taiwan, Republic of China.
Department of Pathology, Tri-Service General Hospital Songshan Branch and School of Medicine, National Defense Medical Center, Taipei, Taiwan, Republic of China.
Public Health Nutr. 2022 Jul;25(7):1745-1750. doi: 10.1017/S1368980022000684. Epub 2022 Mar 23.
Increasing evidence supports sarcopenia as an important parameter for predicting cardiometabolic risks. The objective of this study was to investigate the relationship between muscle mass, muscle strength, and physical performance, and cardiovascular risk among older community-dwelling adults.
The associations between dynapenia, sarcopenia, and Framingham risk score (FRS) were estimated by multivariate regression models.
Muscle mass is estimated by skeletal muscle mass index using a bioelectrical impedance analysis. Muscle strength is measured by handgrip strength using an analogue isometric dynamometer. Physical performance is measured by gait speed using a 6-m walking distance. Dynapenia was defined as low muscle strength and/or slow gait speed presents with normal muscle mass. The diagnosis of presarcopenia and sarcopenia was based on criteria proposed by the Asian Working Group for Sarcopenia in 2014. The FRS was used for evaluating 10-year coronary heart disease (CHD) risk.
Adults aged 65 years and older who attended health examinations from 2015 to 2017 were recruited.
There were totally 709 subjects enrolled in this study. Dynapenic men ( 47) had 17·70 ± 5·08 % FRS and sarcopenic women ( 74) had 7·74 ± 6·06 % FRS. Participants with presarcopenia had the lowest FRS (men: 15·41 ± 5·35 %; women: 5·25 ± 3·70 %). Men with dynapenia had higher FRS than the presarcopenia group with odds ratio (OR) of 2·52 (95 % confidence interval (CI): 1·03, 6·14). Women with sarcopenia had significantly higher FRS than the presarcopenia group with OR of 2·81 (95 % CI: 1·09, 7·27).
Older dynapenic men and older sarcopenic women had higher risks of 10-year CHD. Presarcopenic older adults had the lowest CHD risk in both genders.
越来越多的证据支持肌肉减少症是预测心脏代谢风险的重要参数。本研究的目的是调查老年社区居民的肌肉质量、肌肉力量、身体机能与心血管风险之间的关系。
通过多变量回归模型估计肌肉减少性虚弱、肌肉减少症与弗雷明汉风险评分（FRS）之间的关联。
使用生物电阻抗分析通过骨骼肌质量指数估计肌肉质量。使用模拟等长测力计通过握力测量肌肉力量。使用6米步行距离通过步速测量身体机能。肌肉减少性虚弱定义为肌肉质量正常但存在肌肉力量低和/或步速慢的情况。根据2014年亚洲肌肉减少症工作组提出的标准诊断肌肉减少症前期和肌肉减少症。FRS用于评估10年冠心病（CHD）风险。
招募了2015年至2017年参加健康检查的65岁及以上成年人。
本研究共纳入709名受试者。肌肉减少性虚弱的男性（47名）FRS为17.70±5.08%，肌肉减少症的女性（74名）FRS为7.74±6.06%。肌肉减少症前期的参与者FRS最低（男性：15.41±5.35%；女性：5.25±3.70%）。肌肉减少性虚弱的男性FRS高于肌肉减少症前期组，优势比（OR）为2.52（95%置信区间（CI）：1.03，6.14）。肌肉减少症的女性FRS显著高于肌肉减少症前期组，OR为2.81（95%CI：1.09，7.27）。
老年肌肉减少性虚弱男性和老年肌肉减少症女性患10年冠心病的风险更高。肌肉减少症前期的老年人在两性中患冠心病的风险最低。
