Department of Microbial Pathogenesis, School of Dentistry, University of Maryland, Baltimore, MD 21201, United States.
Gut Microbes. 2022 Jan-Dec;14(1):2052698. doi: 10.1080/19490976.2022.2052698.
is the most prevalent pathogen of nosocomial diarrhea. In the United States, over 450,000 cases of infection (CDI), responsible for more than 29,000 deaths, are reported annually in recent years. Because of the emergence of hypervirulent strains and strains less susceptible to vancomycin and fidaxomicin, new therapeutics other than antibiotics are urgently needed. The gut microbiome serves as one of the first-line defenses against colonization. The use of antibiotics causes gut microbiota dysbiosis and shifts the status from colonization resistance to infection. Hence, novel CDI biotherapeutics capable of reconstituting normal gut microbiota have become a focus of drug development in this field.
是医院获得性腹泻最常见的病原体。近年来，据报道，在美国每年有超过 45 万例 感染（CDI），导致超过 29000 人死亡。由于出现了毒力更强的菌株和对万古霉素和非达霉素敏感性降低的菌株，因此迫切需要除抗生素以外的新疗法。肠道微生物组是抵御 定植的第一道防线之一。抗生素的使用会导致肠道微生物群落失调，并使定植抵抗状态转变为感染状态。因此，能够重建正常肠道微生物群落的新型 CDI 生物治疗药物已成为该领域药物开发的重点。
