Department of Imaging and Radiology, Copenhagen University Hospital - North Zealand Hospital.
Department of Clinical Research, Copenhagen University Hospital - North Zealand Hospital.
Dan Med J. 2022 Mar 16;69(4):A08210633.
We aimed to evaluate post-COVID-19 fatigue, change in functional capacity and health-related quality of life (HRQoL) eight months after discharge from hospital due to COVID-19.
A total of 83 patients (35 women) admitted to the Copenhagen University Hospital - North Zealand Hospital, Denmark, for COVID-19 during the period from March to June 2020 were evaluated eight months after discharge using validated questionnaires quantifying fatigue, HRQoL and post-COVID-19 functional status. Follow-up data were correlated with measures of pre-COVID-19 status (anthropometrics, comorbidities) and measures of severity of the acute infection.
A total of 22 (65%) women and 12 (26%) men reported excessive fatigue. In all, 20 women (67%) and 17 men (37%) reported decreased physical function. Female sex was associated with fatigue. Loss of physical function was associated with pre-COVID-19 presence of heart disease and absence of lung disease. Severity of the acute COVID-19 infection was not associated with fatigue or change in functional status. Fatigue and functional status were correlated with both generic HRQoL and lung disease-specific HRQoL.
Female sex was associated with a higher risk of fatigue eight months after hospitalisation with COVID-19 infection. Regarding loss of functional capacity after COVID-19, we found an apparently protective effect of pre-COVID-19 lung disease. Our findings underscore the urgent need for further research and the importance of evaluating those recovering from COVID-19 for symptoms of excessive fatigue and change in functional capacity irrespective of the severity of the initial infection.
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not relevant.
我们旨在评估 COVID-19 住院治疗 8 个月后新冠后疲劳、功能能力变化和健康相关生活质量（HRQoL）。
2020 年 3 月至 6 月期间，丹麦哥本哈根大学医院-北西兰医院共收治 83 例（35 例女性）COVID-19 患者，在出院 8 个月后使用经过验证的问卷评估疲劳、HRQoL 和 COVID-19 后功能状态。随访数据与 COVID-19 前状态（人体测量、合并症）和急性感染严重程度的测量相关。
共有 22 名（65%）女性和 12 名（26%）男性报告过度疲劳。共有 20 名女性（67%）和 17 名男性（37%）报告体力功能下降。女性性别与疲劳有关。体力功能丧失与 COVID-19 前存在心脏病和无肺病有关。急性 COVID-19 感染的严重程度与疲劳或功能状态变化无关。疲劳和功能状态与一般 HRQoL 和肺病特异性 HRQoL 均相关。
女性在 COVID-19 感染住院后 8 个月发生疲劳的风险更高。关于 COVID-19 后丧失功能能力，我们发现 COVID-19 前肺病有明显的保护作用。我们的研究结果强调了进一步研究的迫切需要，以及评估那些从 COVID-19 中康复的患者是否存在过度疲劳和功能能力变化的重要性，无论初始感染的严重程度如何。
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不相关。
