Department of Chest Diseases, Ankara Atatürk Sanatoryum Education and Research Hospital, University of Health Sciences, Ankara, Turkiye.
Department of Chest Diseases, Süreyyapaşa Chest Diseases and Surgery Education and Research Hospital, İstanbul Provincial Directorate of Health, İstanbul, Turkiye.
Turk J Med Sci. 2024 Jul 14;54(4):623-630. doi: 10.55730/1300-0144.5831. eCollection 2024.
BACKGROUND/AIM: Symptoms of COVID-19 may persist for months. One of the persistent symptoms of COVID-19 is fatigue, which reduces functional status. The relationship between fatigue, functional status, and various other factors has received little attention, which this study aims to address..
Patients with COVID-19 infection were included in this multicenter cross-sectional study. Age, sex, body mass index (BMI), marital status, smoking status, presence and duration of chronic disease, comorbidity index, regular exercise habits, time since COVID-19 diagnosis, hospitalization status, length of hospital stay, intubation status, home oxygen therapy after discharge, participation in a pulmonary rehabilitation program, presence of dyspnea, presence of cough, presence of sputum, and modified Medical Research Council, Post-COVID Functional Status (PCFS), Fatigue Severity Scale (FSS), and EQ-5D-5L Questionnaire scores were recorded.
We enrolled 1095 patients, including 603 (55%) men and 492 (45%) women with a mean age of 50 ± 14 years. The most common chronic lung disease was COPD (11%) and 266 (29%) patients had nonpulmonary disease. The median time elapsed since COVID-19 diagnosis was 5 months; the hospitalization rate was 47%. The median PCFS grade was 1 (0-4) and the median FSS score was 4.4 (1-7). The PCFS and FSS were positively correlated (r = 0.49, p < 0.01; OR: 1.88, 95% CI: 1.68-2.10). Both functional status and fatigue were associated with quality of life, which was lower in older patients, those with higher BMI, those with systemic disease, those not exercising regularly, and those with more severe COVID-19 infection (defined by dyspnea, pneumonia as indicated by computed tomography, hospitalization, length of stay, ICU admission, intubation, and the need for home oxygen after discharge).
Fatigue may cause poorer functional status regardless of the time since COVID-19 diagnosis. In this study, patients with FSS scores of >4.78 showed moderate to severe functional limitations. It is important to address modifiable patient risk factors and reduce the severity of COVID-19 infection.
背景/目的：COVID-19 的症状可能持续数月。COVID-19 的持续症状之一是疲劳，它会降低功能状态。疲劳、功能状态与其他各种因素之间的关系尚未得到充分关注，本研究旨在探讨这一问题。
本多中心横断面研究纳入了 COVID-19 感染患者。记录了患者的年龄、性别、体重指数（BMI）、婚姻状况、吸烟状况、慢性疾病的存在和持续时间、合并症指数、定期运动习惯、COVID-19 诊断后时间、住院状态、住院时间、插管状态、出院后家庭氧疗、参加肺康复计划、呼吸困难的存在、咳嗽的存在、咳痰的存在、改良的医学研究理事会呼吸困难量表（mMRC）、Post-COVID 功能状态（PCFS）、疲劳严重程度量表（FSS）和 EQ-5D-5L 问卷评分。
共纳入 1095 例患者，其中 603 例（55%）为男性，492 例（45%）为女性，平均年龄为 50 ± 14 岁。最常见的慢性肺部疾病为 COPD（11%），266 例（29%）患者患有非肺部疾病。COVID-19 诊断后中位时间为 5 个月；住院率为 47%。PCFS 等级中位数为 1（0-4），FSS 评分中位数为 4.4（1-7）。PCFS 和 FSS 呈正相关（r = 0.49，p < 0.01；OR：1.88，95%CI：1.68-2.10）。功能状态和疲劳均与生活质量相关，年龄较大、BMI 较高、患有系统性疾病、不规律运动以及 COVID-19 感染更严重（呼吸困难、计算机断层扫描显示肺炎、住院、住院时间、重症监护病房入住、插管和出院后家庭氧疗需要）的患者生活质量较低。
无论 COVID-19 诊断后时间如何，疲劳都可能导致较差的功能状态。在这项研究中，FSS 评分>4.78 的患者表现出中度至重度功能受限。重要的是要解决可改变的患者风险因素并降低 COVID-19 感染的严重程度。
