Department of Obstetrics & Gynaecology, Melaka Manipal Medical College, Manipal, India.
Manipal Academy of Higher Education, Manipal, India.
Congenit Anom (Kyoto). 2022 May;62(3):113-122. doi: 10.1111/cga.12463. Epub 2022 Mar 30.
The magnitude of association of skeletal anomalies with maternal diabetes is not known. The systemic review was done to detect the frequency of congenital skeletal malformations with diabetes mellitus in pregnancy in the literature evidence of the past 50 years. Literature on maternal diabetes and skeletal malformation was searched by two independent authors by following PRISMA guidelines. Strict inclusion and exclusion criteria were followed. After quality assessment, 21 original articles were included. The frequency of congenital malformation, skeletal malformation was extracted from the included studies. 11,574 congenital anomalies were detected diabetic mothers. 1182 skeletal anomalies were noted in 20,11 552 diabetic mothers. The skeletal malformation was noted in 20.4% of total anomalies. The most common skeletal malformation was the defect of the spine (39.9%). The limb deficiency was found in 32.8% of the infants of diabetic mothers. The skeletal malformations were higher, that is, 24.6% in pre-gestational diabetes. The incidence of skeletal malformation from the evidence was 1.5% (range: 0.03-4.27%) in maternal diabetes. Pre-gestation diabetes is more frequently associated with skeletal malformations, which is 1.9% (range: 0.07-5.89%). The association of congenital malformations and skeletal malformations in diabetic pregnancy is significant and hence, effective management of diabetes in childbearing age is essential to reduce this incidence and related long-term morbidity.
骨骼异常与母体糖尿病之间的关联程度尚不清楚。本系统评价旨在检测过去 50 年文献中妊娠糖尿病与先天性骨骼畸形的相关性。两位作者按照 PRISMA 指南搜索了关于母体糖尿病和骨骼畸形的文献。严格遵循纳入和排除标准。经过质量评估，纳入了 21 篇原始文章。从纳入的研究中提取了先天性畸形、骨骼畸形的频率。在 11574 例先天性异常中，有 1182 例在糖尿病母亲中发现骨骼异常。在 2011552 例糖尿病母亲中，发现 20.4%的总畸形为骨骼畸形。最常见的骨骼畸形是脊柱缺陷（39.9%）。在糖尿病母亲的婴儿中，肢体缺失占 32.8%。骨骼畸形较高，即孕前糖尿病中为 24.6%。从证据来看，骨骼畸形在母体糖尿病中的发病率为 1.5%（范围：0.03-4.27%）。孕前糖尿病与骨骼畸形的相关性更高，为 1.9%（范围：0.07-5.89%）。糖尿病妊娠中先天性畸形和骨骼畸形的相关性是显著的，因此，对育龄期糖尿病进行有效管理对于降低这种发病率和相关的长期发病率至关重要。
