甲状腺病变的细胞学和组织病理学相关性。
Cytological and histopathological correlation of thyroid lesions.
机构信息
Department of Histopathology and Cytopathology, Shaukat Khanum Memorial Cancer Hospital and Research Center, Lahore, Pakistan.
Department of Histopathology and Cytopathology, Queens Medical Center, Nottingham University Hospital, United Kingdom.
出版信息
J Pak Med Assoc. 2022 Feb;72(2):300-304. doi: 10.47391/JPMA.2224.
OBJECTIVE
To determine accuracy of cytological diagnosis in comparison with the corresponding histopathological diagnosis of thyroid lesions.
METHODS
The retrospective study was conducted at the Shaukat Khanum Memorial Cancer Hospital, Lahore, Pakistan, and comprised data from January to December 2017 of all in-patient cases of thyroid cytology with their histopathological diagnosis. Both Haematoxylin and Eosin stain slides and cytological smears were reviewed. True negative, true positive, false negative and false positive cases were marked using the criteria defined in Table-1.
RESULTS
Of the total 36 cases, 5(13.9%) were non-diagnostic or unsatisfactory for cytological assessment. Cytological diagnosis achieved sensitivity of 82.3%, specificity 64.3%, positive predictive value 73.6%, negative predictive value 75%, false positive rate 35.7% and false negative rate 17.6%. The diagnostic accuracy of cytological diagnosis was 63.9%.
CONCLUSIONS
There was significant cytological and histopathological concordance of thyroid lesions.
目的
比较细胞学诊断与甲状腺病变的相应组织病理学诊断的准确性。
方法
该回顾性研究在巴基斯坦拉合尔沙迦汗纪念癌症医院进行，纳入了 2017 年 1 月至 12 月所有甲状腺细胞学住院患者及其组织病理学诊断的资料。对苏木精和伊红染色切片和细胞学涂片进行了回顾。使用表 1 中定义的标准标记真阴性、真阳性、假阴性和假阳性病例。
结果
在 36 例患者中，有 5 例（13.9%）细胞学评估不满意或不明确。细胞学诊断的敏感性为 82.3%，特异性为 64.3%，阳性预测值为 73.6%，阴性预测值为 75%，假阳性率为 35.7%，假阴性率为 17.6%。细胞学诊断的准确性为 63.9%。
结论
甲状腺病变的细胞学和组织病理学具有显著的一致性。
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