School of Stomatology, Zunyi Medical University, No. 6 West Xuefu Road, Xinpu District, Zunyi, 563006, Guizhou, China.
Special Key Laboratory of Oral Disease Research of Higher Education Institution of Guizhou Province, Zunyi Medical University, Zunyi, Guizhou, China.
Tissue Eng Regen Med. 2022 Jun;19(3):451-461. doi: 10.1007/s13770-022-00432-w. Epub 2022 Mar 23.
The oral and maxillofacial region contains oral organs and facial soft tissues. Due to the complexity of the structures and functions of this region, the repair of related defects is complicated. Different degrees of defects require different repair methods, which involve a great combination of medicine and art, and the material requirements are extremely high. Hence, clinicians are plagued by contemporary oral repair materials due to the limitations of bone harvesting, immune rejection, low osteogenic activity and other problems. Decellularized extracellular matrix has attracted much attention as a bioactive scaffold material because of its nonimmunogenic properties, good osteogenic properties, slow release of growth factors, promotion of seed cell adhesion and maintenance of stem cell characteristics. This article reviews the sources, preparation methods, application and research progress of extracellular matrix materials in the repair of oral and maxillofacial defects to provide an overview for fundamental research and clinical development.
口腔颌面部包含口腔器官和面部软组织。由于该区域结构和功能的复杂性，相关缺陷的修复较为复杂。不同程度的缺陷需要不同的修复方法，涉及到医学和艺术的高度结合，并且对材料的要求极高。因此，由于骨采集、免疫排斥、成骨活性低等问题的限制，临床医生被当代口腔修复材料所困扰。去细胞细胞外基质作为一种生物活性支架材料引起了广泛关注，因为它具有非免疫原性、良好的成骨特性、生长因子缓慢释放、促进种子细胞黏附和维持干细胞特性。本文综述了细胞外基质材料在口腔颌面部缺损修复中的来源、制备方法、应用和研究进展，为基础研究和临床开发提供了概述。
