Li Xingrui, Wang Yue, Huang Denghao, Jiang Zhonghao, He Zhiyu, Luo Maoxuan, Lei Jie, Xiao Yao
Oral & Maxillofacial Reconstruction and Regeneration of Luzhou Key Laboratory, the Affiliated Stomatological Hospital of Southwest Medical University, Institute of Stomatology, Southwest Medical University, Luzhou, People's Republic of China.
Department of Orthodontics, the Affiliated Stomatological Hospital of Southwest Medical University, Luzhou, People's Republic of China.
Int J Nanomedicine. 2023 Sep 21;18:5377-5406. doi: 10.2147/IJN.S418675. eCollection 2023.
The critical challenges in repairing oral soft and hard tissue defects are infection control and the recovery of functions. Compared to conventional tissue regeneration methods, nano-bioactive materials have become the optimal materials with excellent physicochemical properties and biocompatibility. Dental-derived mesenchymal stem cells (DMSCs) are a particular type of mesenchymal stromal cells (MSCs) with great potential in tissue regeneration and differentiation. This paper presents a review of the application of various nano-bioactive materials for the induction of differentiation of DMSCs in oral and maxillofacial restorations in recent years, outlining the characteristics of DMSCs, detailing the biological regulatory effects of various nano-materials on stem cells and summarizing the material-induced differentiation of DMSCs into multiple types of tissue-induced regeneration strategies. Nanomaterials are different and complementary to each other. These studies are helpful for the development of new nanoscientific research technology and the clinical transformation of tissue reconstruction technology and provide a theoretical basis for the application of nanomaterial-modified dental implants. We extensively searched for papers related to tissue engineering bioactive constructs based on MSCs and nanomaterials in the databases of PubMed, Medline, and Google Scholar, using keywords such as "mesenchymal stem cells", "nanotechnology", "biomaterials", "dentistry" and "tissue regeneration". From 2013 to 2023, we selected approximately 150 articles that align with our philosophy.
修复口腔软硬组织缺损面临的关键挑战是感染控制和功能恢复。与传统组织再生方法相比，纳米生物活性材料凭借其优异的物理化学性质和生物相容性，已成为理想材料。牙源性间充质干细胞（DMSCs）是间充质基质细胞（MSCs）的一种特殊类型，在组织再生和分化方面具有巨大潜力。本文综述了近年来各种纳米生物活性材料在口腔颌面修复中诱导DMSCs分化的应用，概述了DMSCs的特性，详述了各种纳米材料对干细胞的生物学调控作用，并总结了材料诱导DMSCs分化为多种组织的诱导再生策略。纳米材料各不相同且相互补充。这些研究有助于新型纳米科学研究技术的发展以及组织重建技术的临床转化，并为纳米材料改性牙种植体的应用提供理论依据。我们在PubMed、Medline和谷歌学术数据库中广泛搜索与基于MSCs和纳米材料的组织工程生物活性构建体相关的论文，使用了“间充质干细胞”、“纳米技术”、“生物材料”、“牙科”和“组织再生”等关键词。从2013年到2023年，我们筛选出了约150篇符合我们理念的文章。
