Renfordt E
Psychiatr Dev. 1986 Summer;4(2):135-46.
Reduced speech activity is an important nonverbal symptom of retarded depressions. But speech patterns are also related to many other factors. Under an antidepressive drug treatment the speech behavior could be influenced not only by the therapeutic improvement but also by special pharmacological side effects. In a double-blind trial 21 endogenously depressed inpatients were treated with amitriptyline or pirlindol. Diagnostic interviews with the patients were recorded on TV-tapes on day 0, 4, 7, 14, 21 and 28. To investigate the psychopathological changes the tapes were analyzed under time-blind conditions. The AMP documented results of these ratings showed significantly better therapeutic effects in the amitriptyline-group than in the pirlindol-group. To study speech variables the tapes were computer analyzed. After 4 weeks the degree of improvement in the total group of patients was significantly correlated with the reduced length of speech pauses of both patients and interviewers. On the other hand remarkable drug influences in the course of speech variables were found. These could be interpreted as specific pharmacological effects.
言语活动减少是迟发性抑郁症的一个重要非言语症状。但言语模式也与许多其他因素有关。在抗抑郁药物治疗下，言语行为不仅会受到治疗改善的影响，还会受到特殊药理副作用的影响。在一项双盲试验中，21名内因性抑郁症住院患者接受了阿米替林或匹克隆的治疗。在第0、4、7、14、21和28天，对患者的诊断性访谈被录制在录像带上。为了研究心理病理学变化，这些录像带在时间盲视条件下进行了分析。AMP记录的这些评分结果显示，阿米替林组的治疗效果明显优于匹克隆组。为了研究言语变量，对录像带进行了计算机分析。4周后，患者总群体的改善程度与患者和访谈者言语停顿时间的缩短显著相关。另一方面，在言语变量过程中发现了显著的药物影响。这些可以被解释为特定的药理作用。
