Department of Obstetrics and Gynecology, Beijing Chaoyang Hospital Affiliated to Capital Medical University, Beijing, China.
J Healthc Eng. 2022 Mar 14;2022:5422748. doi: 10.1155/2022/5422748. eCollection 2022.
To analyze the distribution of human papilloma virus (HPV) infection in women with cervical lesions of different grades and analyze the relationship of high-risk HPV and cervical lesions in order to facilitate targeted prevention.
The infection status of HPV subtype was statistically analyzed in patients who underwent colposcopy examination from April 2017 to June 2019.
The infection rate of HPV was 81.4% in chronic cervicitis, 82.9% in 1ow-grade squamous intraepithelial lesion (LSIL), 63.7% in HSIL (high-grade squamous intraepithelial lesion), and 50% in cervical squamous cell carcinoma (CSCC). Among the 16 high-risk HPV types, the top six HPV types with the comprehensive infection rates were HPV16 > HPV52 > HPV58 > HPV18 > HPV51 > HPV53 in turn, and the infection rates were 23.3%, 14.8%, 13.3%, 9.8%, 9.2%, and 8.8%, respectively. The infection rates of HPV16 in chronic cervicitis group, LSIL group, and HSIL group were significantly different. There was no significant difference in the injection rates of HPV52, HPV58, and HPV18 among the three groups. HPV infection rates were highest in the 31-40 years old group, followed by the 41-50 years old group.
The distribution of different types of HPV varies in different tissue types, which can be used to develop relevant vaccines to achieve better prevention and treatment of cervical cancer.
分析不同级别宫颈病变妇女人乳头瘤病毒（HPV）感染分布情况，分析高危型 HPV 与宫颈病变的关系，以便于有针对性地进行预防。
对 2017 年 4 月至 2019 年 6 月行阴道镜检查的患者进行 HPV 亚型感染状况统计分析。
慢性宫颈炎 HPV 感染率为 81.4%，低级别鳞状上皮内病变（LSIL）为 82.9%，高级别鳞状上皮内病变（HSIL）为 63.7%，宫颈鳞状细胞癌（CSCC）为 50%。在 16 种高危型 HPV 中，综合感染率前 6 位的 HPV 类型依次为 HPV16>HPV52>HPV58>HPV18>HPV51>HPV53，感染率分别为 23.3%、14.8%、13.3%、9.8%、9.2%、8.8%。HPV16 在慢性宫颈炎组、LSIL 组和 HSIL 组的感染率差异有统计学意义。HPV52、HPV58、HPV18 在三组间的注射率差异无统计学意义。HPV 感染率最高的为 31-40 岁年龄组，其次为 41-50 岁年龄组。
不同类型 HPV 在不同组织类型中的分布不同，可据此开发相关疫苗，以达到更好的宫颈癌防治效果。
