Institute of Virology, Wenzhou University, Wenzhou, China.
Key Laboratory of Virology and Immunology of Wenzhou, Wenzhou University, Wenzhou, China.
Front Cell Infect Microbiol. 2022 Mar 7;12:860559. doi: 10.3389/fcimb.2022.860559. eCollection 2022.
Human adenovirus (HAdV) has a worldwide distribution and remains a major pathogen that leads to infections of the respiratory tract. No specific treatments or vaccines are yet available for HAdV infection. , an edible seaweed, has attracted a lot of attention for its various bioactivities. has been reported to exhibit antiviral activity. However, research studies about its anti-HAdV activity are few. In this research, we found that had low cytotoxicity and possessed anti-human adenovirus type 7 (HAdV7) activity , and the most effective ingredient was alginate. The time of addition assay demonstrated inhibitory effects that were observed in all life stages of the virus. In addition, we observed that the antiviral activity of alginate against HAdV7 infection might be closely related to the endoplasmic reticulum stress (ERS) pathway. Taken together, these results suggest that extracts have potential application in the prevention and treatment of HAdV infection.
人腺病毒（HAdV）分布广泛，仍是导致呼吸道感染的主要病原体。目前尚无针对 HAdV 感染的特效治疗方法或疫苗。裙带菜是一种可食用的海藻，因其多种生物活性而备受关注。已有研究报道其具有抗病毒活性，但关于其抗 HAdV 活性的研究较少。本研究发现裙带菜提取物具有低细胞毒性和抗人腺病毒 7 型（HAdV7）活性，其中最有效的成分是褐藻酸盐。添加时间测定实验表明，褐藻酸盐对 HAdV7 的所有生命周期均具有抑制作用。此外，我们还观察到褐藻酸盐对 HAdV7 感染的抗病毒活性可能与内质网应激（ERS）途径密切相关。综上所述，这些结果提示裙带菜提取物具有预防和治疗 HAdV 感染的应用潜力。
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