College of Life and Environmental Science, Wenzhou University, Wenzhou 325035, China.
Environmental Science and Environmental Engineering, University of Northern British Columbia, Prince George, British Columbia, Canada V2N 4Z9.
J Agric Food Chem. 2020 Sep 30;68(39):10626-10638. doi: 10.1021/acs.jafc.0c02555. Epub 2020 Sep 10.
fucoidan (SFF) exhibits diverse biological activities. Insulin resistance (IR) implicated in type 2 diabetes (T2D) has become an epidemic health issue worldwide. In this study, we investigated whether SFF can improve insulin sensitivity in high-fat diet (HFD)-fed mice. Our present data showed that SFF significantly reduced fasting blood glucose and IR index along with improved glucose tolerance. Impaired phosphorylation of Akt was also restored by SFF. Furthermore, SFF decreased the levels of MDA and 4-HNE-modified protein and increased GSH/GSSG ratio as well as elevated antioxidant enzymes and activated Nrf2 signaling. SFF also increased the abundance and diversity of gut microbiota in the obese mice, as well as improved intestinal integrity and inflammation. Our findings suggested that SFF ameliorated HFD-induced IR through activating the Nrf2 pathway, remodeling gut microbiota, and reducing intestinal inflammation, thus providing a novel perspective into the treatment strategy on metabolic disease.
岩藻聚糖硫酸酯（SFF）具有多种生物学活性。2 型糖尿病（T2D）中涉及的胰岛素抵抗（IR）已成为全球范围内的流行健康问题。在这项研究中，我们研究了 SFF 是否可以改善高脂肪饮食（HFD）喂养的小鼠的胰岛素敏感性。我们目前的数据表明，SFF 可显著降低空腹血糖和 IR 指数，改善葡萄糖耐量。SFF 还恢复了 Akt 的磷酸化。此外，SFF 降低了 MDA 和 4-HNE 修饰蛋白的水平，增加了 GSH/GSSG 比值，并提高了抗氧化酶的活性和 Nrf2 信号通路的激活。SFF 还增加了肥胖小鼠肠道微生物群的丰度和多样性，改善了肠道完整性和炎症。我们的研究结果表明，SFF 通过激活 Nrf2 通路、重塑肠道微生物群和减少肠道炎症来改善 HFD 诱导的 IR，从而为代谢性疾病的治疗策略提供了新的视角。
