Vincent J L, Domb M, Goldstein J, Lignian H, Van Belle J
Prostaglandins Leukot Med. 1986 Sep;24(1):87-92. doi: 10.1016/0262-1746(86)90211-8.
Prostacyclin (PGI2) has been shown to present myocardial protective effects which could be beneficial during cardiac arrest. We tested this hypothesis in a closed-chest dog model in which electromechanical dissociation (EMD) can be predictably observed after 90 to 120 seconds of ventricular fibrillation without chest compression. Six dogs were pretreated with a PGI2 infusion at a rate of 1 mcg/kg/min and six other dogs served as control animals. After 60 seconds of ventricular fibrillation, EMD was already observed in 3 PGI2-treated dogs but in no control dog. After 90 seconds of ventricular fibrillation, EMD was present in 2 PGI2-treated dogs and in 2 control dogs, so that 4 control but only one PGI2-treated animal survived after 90 seconds of ventricular fibrillation. Ventricular defibrillation was also not facilitated in PGI2-treated dogs. The present study does not support PGI2 administration in cardiopulmonary resuscitation.
前列环素（PGI2）已被证明具有心肌保护作用，这在心脏骤停期间可能是有益的。我们在一个闭胸犬模型中验证了这一假设，在该模型中，心室颤动90至120秒且无胸部按压后，可预测地观察到电机械分离（EMD）。六只犬以1 mcg/kg/分钟的速率预先输注PGI2，另外六只犬作为对照动物。心室颤动60秒后，3只接受PGI2治疗的犬已观察到EMD，但对照犬均未出现。心室颤动90秒后，2只接受PGI2治疗的犬和2只对照犬出现EMD，因此心室颤动90秒后，4只对照动物存活，而接受PGI2治疗的动物只有1只存活。PGI2治疗的犬也未促进心室除颤。本研究不支持在心肺复苏中使用PGI2。
