Blecic S, De Backer D, Huynh C H, Deleuze M, Domb M, Luypaert P, Vincent J L
Crit Care Med. 1987 Apr;15(4):324-7. doi: 10.1097/00003246-198704000-00009.
While calcium administration has been recommended in CPR, its beneficial effects have been challenged. The effectiveness of calcium chloride was evaluated and compared with epinephrine during successive episodes of electromechanical dissociation (EMD) after ventricular fibrillation in closed-chest dogs. Each of three successive episodes of CPR was randomly and blindly treated by repeated (every 2 min) injections of 5 ml H2O plus either 500 mg of calcium chloride (CaCl2), 1 mg of epinephrine (Epi), or 5% dextrose (D5W). Of 42 CPR attempts performed on 16 dogs, 16 were reversed by only chest compression and artificial ventilation. For the 26 CPR with pharmacologic intervention, recovery was obtained after one injection in 5 of 6 Epi but only in 4 of 11 CaCl2 and 4 of 9 D5W. Only four CPR attempts were ultimately unsuccessful, all in CaCl2 group. During recovery, the Epi group showed significantly higher arterial pressures and heart rates but less severe acidemia. In this model, calcium chloride alone is ineffective during EMD.
虽然在心肺复苏术中推荐使用钙剂，但其有益效果受到了质疑。在闭胸犬室颤后的连续电机械分离（EMD）发作期间，评估了氯化钙的有效性，并与肾上腺素进行了比较。连续三次心肺复苏发作中的每一次均通过重复（每2分钟）注射5毫升水加500毫克氯化钙（CaCl2）、1毫克肾上腺素（Epi）或5%葡萄糖（D5W）进行随机、盲法治疗。在对16只犬进行的42次心肺复苏尝试中，16次仅通过胸外按压和人工通气得以逆转。对于26次进行了药物干预的心肺复苏，6次使用肾上腺素的尝试中有5次在注射一次后恢复自主循环，但11次使用氯化钙的尝试中只有4次，9次使用5%葡萄糖的尝试中只有4次恢复自主循环。最终只有4次心肺复苏尝试未成功，均在氯化钙组。在恢复过程中，肾上腺素组的动脉压和心率显著更高，但酸中毒程度较轻。在该模型中，单独使用氯化钙在电机械分离期间无效。
