Department of Clinical Sciences, College of Veterinary Medicine, China Agricultural University, Beijing, People's Republic of China.
College of Veterinary Medicine & Biomedical Sciences, Texas A&M University, College Station, TX, USA.
J Vet Diagn Invest. 2022 Jul;34(4):577-586. doi: 10.1177/10406387221081232. Epub 2022 Mar 23.
Bovine respiratory disease complex (BRDC) is a common, serious problem in feedlot cattle worldwide. Early diagnosis and outcome prediction are critical for making decisions to prevent economic loss and to limit antimicrobial use. Diagnosing BRDC is commonly based on visual signs and behavioral changes; both assessments are considered to have low diagnostic accuracy. Biomarkers are important for supporting the diagnosis of BRDC, determining the necessity and potential outcomes of treatment, and assisting in research in which differentiating diseased animals is required. There are few reviews summarizing the biomarkers available and utilized. We systematically evaluated the detection and prognostic potential of biomarkers from the literature published between January 1990 and December 2020. We performed a descriptive analysis of 5 biomarker categories: acute-phase proteins, stress-related hormones, other blood biomarkers, omics biomarkers, and non-blood biomarkers. The retrieved articles consisted of studies or trials that assessed the detection value and treatment and/or outcome prediction efficacy of biomarkers for BRDC in feedlot cattle; 23 manuscripts for review and analysis satisfied the selection criteria. Based on our review, we cannot recommend a specific biomarker as the sole method for the early detection or outcome prediction for BRDC, given that the application and efficacy of biomarkers varies in different situations. Our systematic review may serve as a reference for clinical and research investigations of early detection and outcome prediction of BRDC.
牛呼吸道疾病复合症（BRDC）是全球饲养场牛群中常见且严重的问题。早期诊断和预后预测对于做出决策以防止经济损失和限制抗生素使用至关重要。BRDC 的诊断通常基于视觉迹象和行为变化；这两种评估方法的诊断准确性都较低。生物标志物对于支持 BRDC 的诊断、确定治疗的必要性和潜在结果以及协助需要区分患病动物的研究非常重要。目前很少有综述总结可用和已用的生物标志物。我们系统地评估了 1990 年 1 月至 2020 年 12 月期间发表的文献中生物标志物的检测和预后潜力。我们对 5 种生物标志物类别进行了描述性分析：急性期蛋白、应激相关激素、其他血液生物标志物、组学生物标志物和非血液生物标志物。检索到的文章包括评估 BRDC 饲养场牛生物标志物检测价值以及治疗和/或预后预测效果的研究或试验；有 23 篇文章符合选择标准进行了综述和分析。根据我们的综述，由于生物标志物在不同情况下的应用和效果不同，我们不能推荐特定的生物标志物作为 BRDC 早期检测或预后预测的唯一方法。我们的系统评价可以为 BRDC 的早期检测和预后预测的临床和研究调查提供参考。
