Biotechnology Research Center and Department of Biotechnology, Toyama Prefectural University, 5180 Kurokawa, Imizu, Toyama, 939-0398, Japan.
J Antibiot (Tokyo). 2022 May;75(5):296-300. doi: 10.1038/s41429-022-00519-5. Epub 2022 Mar 23.
Trehangelin E (1), a new bisacyl trehalose, was isolated from the culture extract of an actinomycete Polymorphospora sp. RD064483, along with three known congeners, trehangelins A, B, and D. Compound 1 is a new trehalose derivative acylated with (Z)-2-methyl-2-butenoic acid (angelic acid) at 3- and 6'-positions, as determined by NMR and MS analyses. Compound 1 promoted root elongation of germinated lettuce seeds by 30% at 1 μM and 90% at 10 μM compared to the nontreated seeds. Similar promoting activity of root elongation was also observed with trehangelins A and B at the same level.
特雷汉林 E（1）是一种新的双酰基海藻糖，从放线菌 Polymorphospora sp. RD064483 的培养提取物中分离得到，同时还分离得到了三种已知的同系物，即特雷汉林 A、B 和 D。化合物 1 是一种新的海藻糖衍生物，在 3-位和 6'-位被（Z）-2-甲基-2-丁烯酸（当归酸）酰化，这是通过 NMR 和 MS 分析确定的。与未经处理的种子相比，化合物 1 在 1 μM 时促进发芽生菜种子根伸长 30%，在 10 μM 时促进 90%。在相同水平下，特雷汉林 A 和 B 也表现出类似的促进根伸长的活性。
