Biotechnology Research Center and Department of Biotechnology, Toyama Prefectural University, 5180 Kurokawa, Imizu, Toyama, 939-0398, Japan.
J Antibiot (Tokyo). 2023 Jul;76(7):392-396. doi: 10.1038/s41429-023-00614-1. Epub 2023 Apr 4.
Microbispofurans A-C (1-3), new alkyl/alkenyl furancarboxylic acids, were isolated from the culture extract of the plant root-derived Microbispora sp. RD004716. The planar structures of 1-3 were determined by extensive analysis of 1D and 2D NMR spectroscopic data. Although 1-3 showed no appreciable antimicrobial activity or cytotoxicity, strong plant growth-promotion activity of the germinated red leaf lettuce seeds was observed at 10 μM. Furancarboxylic acids and their methyl esters were found in actinomycetes and fungi; however, the isolation of furandicarboxylic acid was unprecedented.
微生物呋喃 A-C（1-3），新的烷基/烯基呋喃羧酸，从植物根衍生的微杆菌 RD004716 的培养物提取物中分离得到。通过对 1D 和 2D NMR 谱数据的广泛分析，确定了 1-3 的平面结构。尽管 1-3 没有表现出明显的抗菌活性或细胞毒性，但在 10 μM 时，发芽的红色生菜种子表现出很强的促生长活性。呋喃羧酸及其甲酯存在于放线菌和真菌中；然而，呋喃二羧酸的分离是前所未有的。
