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The role of PI3Kγ in the immune system: new insights and translational implications.
Nat Rev Immunol. 2022 Nov;22(11):687-700. doi: 10.1038/s41577-022-00701-8. Epub 2022 Mar 23.
2
Targeting phosphatidylinositol 3-kinase gamma (PI3Kγ): Discovery and development of its selective inhibitors.
Med Res Rev. 2021 May;41(3):1599-1621. doi: 10.1002/med.21770. Epub 2020 Dec 10.
3
Phosphoinositide 3 Kinase γ Plays a Critical Role in Acute Kidney Injury.
Cells. 2022 Feb 23;11(5):772. doi: 10.3390/cells11050772.
4
Designing Small Molecule PI3Kγ Inhibitors: A Review of Structure-Based Methods and Computational Approaches.
J Med Chem. 2024 Jul 11;67(13):10530-10547. doi: 10.1021/acs.jmedchem.4c00347. Epub 2024 Jun 19.
5
A class of highly selective inhibitors bind to an active state of PI3Kγ.
Nat Chem Biol. 2019 Apr;15(4):348-357. doi: 10.1038/s41589-018-0215-0. Epub 2019 Feb 4.
6
Evolution of PI3Kγ and δ Inhibitors for Inflammatory and Autoimmune Diseases.
J Med Chem. 2019 May 23;62(10):4783-4814. doi: 10.1021/acs.jmedchem.8b01298. Epub 2018 Dec 24.
8
PI3Kγ is a molecular switch that controls immune suppression.
Nature. 2016 Nov 17;539(7629):437-442. doi: 10.1038/nature19834. Epub 2016 Sep 19.
10
PI3K Regulatory Protein p84 Determines Mast Cell Sensitivity to Ras Inhibition-Moving Towards Cell Specific PI3K Targeting?
Front Immunol. 2020 Oct 28;11:585070. doi: 10.3389/fimmu.2020.585070. eCollection 2020.

引用本文的文献

2
The genomic legacy of selectively breeding rhesus macaques for HIV/AIDS-related research.
bioRxiv. 2025 May 28:2025.05.26.654976. doi: 10.1101/2025.05.26.654976.
7
Vps34-orchestrated lipid signaling processes regulate the transitional heterogeneity and functional adaptation of effector regulatory T cells.
PLoS Biol. 2025 Apr 11;23(4):e3003074. doi: 10.1371/journal.pbio.3003074. eCollection 2025 Apr.
8
PI3K Inhibitors as Potential Therapeutic Agents for the Treatment of COPD with Associated Atherosclerosis.
Drugs. 2025 Jun;85(6):741-753. doi: 10.1007/s40265-025-02179-9. Epub 2025 Apr 11.
9
PI3K pathway activation in severe asthma is linked to steroid insensitivity and adverse outcomes.
J Allergy Clin Immunol Glob. 2025 Feb 12;4(2):100439. doi: 10.1016/j.jacig.2025.100439. eCollection 2025 May.
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1
Discovery of AZD8154, a Dual PI3Kγδ Inhibitor for the Treatment of Asthma.
J Med Chem. 2021 Jun 24;64(12):8053-8075. doi: 10.1021/acs.jmedchem.1c00434. Epub 2021 Jun 3.
3
Germline biallelic PIK3CG mutations in a multifaceted immunodeficiency with immune dysregulation.
Haematologica. 2020 Oct 1;105(10):e488. doi: 10.3324/haematol.2019.231399.
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The Growing Spectrum of Human Diseases Caused by Inherited CDC42 Mutations.
J Clin Immunol. 2020 May;40(4):551-553. doi: 10.1007/s10875-020-00785-8.
5
T cell subsets and functions in atherosclerosis.
Nat Rev Cardiol. 2020 Jul;17(7):387-401. doi: 10.1038/s41569-020-0352-5. Epub 2020 Mar 16.
7
Class I phosphoinositide 3-kinase (PI3K) regulatory subunits and their roles in signaling and disease.
Adv Biol Regul. 2020 Jan;75:100657. doi: 10.1016/j.jbior.2019.100657. Epub 2019 Sep 28.
10
Insulin-Driven PI3K-AKT Signaling in the Hepatocyte Is Mediated by Redundant PI3Kα and PI3Kβ Activities and Is Promoted by RAS.
Cell Metab. 2019 Jun 4;29(6):1400-1409.e5. doi: 10.1016/j.cmet.2019.03.010. Epub 2019 Apr 11.

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