Barbara L, Corinaldesi B, Stanghellini V, Paternicò A, Fabbri L, Sacco T
Scand J Gastroenterol Suppl. 1986;121:1-5. doi: 10.3109/00365528609091670.
Peptic ulcer results from the prevalence of agents causing endoluminal lesions over the defence mechanisms of the mucosa of the upper GI tract. Particularly, in the case of duodenal ulcer, the pathogenetic relevance of non-buffered acid secretion of the early nighttime period has been emphasized. This is indeed confirmed by the fact that a single night dose of 800 mg cimetidine has apparently been proved able--in numerous controlled clinical trials--to provide results that are similar to those obtained with the classic dose of 1 g daily or 400 mg twice daily. Our centre carried out a crossover double-blind controlled trial aimed at evaluating titrable acidity and pH during the 24-h period in seven patients with active duodenal ulcer. The single nighttime dose of cimetidine resulted in a significant and long-lasting inhibition of acid secretion during the entire night. During the day, secretory values returned to levels similar to those obtained with placebo, hence allowing normal digestive functions.
消化性溃疡是由于导致腔内病变的因素超过上消化道黏膜防御机制而引起的。特别是在十二指肠溃疡的情况下，夜间早期无缓冲胃酸分泌的发病机制相关性已得到强调。事实上，在众多对照临床试验中，单次夜间剂量800毫克西咪替丁显然已被证明能够产生与经典剂量每日1克或每日两次400毫克相似的结果，这证实了上述观点。我们中心进行了一项交叉双盲对照试验，旨在评估7例活动性十二指肠溃疡患者24小时内可滴定酸度和pH值。单次夜间剂量的西咪替丁导致整个夜间胃酸分泌受到显著且持久的抑制。白天，分泌值恢复到与安慰剂相似的水平，从而使消化功能正常。
