Capurso L, Dal Monte P R, Mazzeo F, Menardo G, Morettini A, Saggioro A, Tafner G
Scand J Gastroenterol Suppl. 1986;121:6-10. doi: 10.3109/00365528609091671.
A multicentre double-blind study was carried out on a total of 197 patients, to evaluate the safety and efficacy of an 800 mg nighttime dose of cimetidine in comparison with 400 mg twice daily in the treatment of duodenal ulcer. At 4 weeks 84% of the 187 patients eligible for analysis had healed ulcers with the once daily regimen and 68% with the twice daily regimen (p less than 0.05). An early decrease in both day and nighttime pain and in antacid consumption was observed during the first 2 weeks. Adverse effects were few and mild, confirming the safety profile of cimetidine.
对总共197例患者进行了一项多中心双盲研究，以评估夜间服用800毫克西咪替丁与每日两次服用400毫克西咪替丁治疗十二指肠溃疡的安全性和疗效。在4周时，187例符合分析条件的患者中，84%采用每日一次方案溃疡已愈合，采用每日两次方案的为68%（P<0.05）。在最初2周内观察到白天和夜间疼痛以及抗酸剂消耗量均早期下降。不良反应少且轻微，证实了西咪替丁的安全性。
