Dickson B
Scand J Gastroenterol Suppl. 1986;121:11-6. doi: 10.3109/00365528609091672.
A multicenter study was carried out on a total of 574 patients to investigate the safety and efficacy of a 800-mg nighttime dose of cimetidine in comparison with 400 mg twice daily for 4 or 8 weeks in the treatment of patients with duodenal ulcer. No statistically significant differences were observed between the two regimens. Healing rates were as follows: at 4 weeks 212 of 269 patients (79%) healed with the once daily regimen whereas 200 of 270 patients (74%) healed with the twice daily dosage; at 8 weeks 242 of 251 patients (96%) healed with the once daily regimen as compared with 232 of 246 (94%) treated with the twice daily dosage. The dosages were equally effective in relief of pain during the study period. The results confirm that a single nighttime dose of cimetidine is as effective as the twice daily regimen.
一项多中心研究共纳入574例患者，旨在研究夜间服用800毫克西咪替丁与每日两次服用400毫克，持续4周或8周治疗十二指肠溃疡患者的安全性和有效性。两种治疗方案之间未观察到统计学上的显著差异。愈合率如下：4周时，每日一次方案治疗的269例患者中有212例（79%）愈合，而每日两次给药方案治疗的270例患者中有200例（74%）愈合；8周时，每日一次方案治疗的251例患者中有242例（96%）愈合，相比之下，每日两次给药方案治疗的246例患者中有232例（94%）愈合。在研究期间，两种剂量在缓解疼痛方面同样有效。结果证实，夜间单次服用西咪替丁与每日两次给药方案效果相同。
