Lončar-Brzak Božana, Škrinjar Ivana, Brailo Vlaho, Vidović-Juras Danica, Šumilin Lada, Andabak-Rogulj Ana
Department of Oral Medicine, School of Dental Medicine, University of Zagreb, 10000 Zagreb, Croatia.
Department of Oral Medicine, University Clinical Hospital Zagreb, 10000 Zagreb, Croatia.
Dent J (Basel). 2022 Mar 10;10(3):44. doi: 10.3390/dj10030044.
The objective of this study was to determine the most effective treatment option for burning mouth syndrome.
Informative treatment alone, B vitamin injections, oral cavity probiotics, and low-level laser therapy were evaluated and compared. The study included new patients diagnosed with burning mouth syndrome, who were randomly allocated into one of four treatment groups. The primary outcome was improvement in patient's quality of life as determined by a self-perceived Oral Health Impact Profile-14 (OHIP-14) quality of life questionnaire before and after therapy. The secondary outcome was determination of mucosal symptom intensity according to visual analog scale (VAS) grading from 0 to 10. Data were submitted to statistical analysis.
A total of 62 patients completed the study. Oral cavity probiotics and LLLT scores for OHIP-14 resulted in a statistically significant difference before and after therapy. Standardized effect sizes between OHIP scores before and after treatment were the greatest for patients who had received oral cavity probiotics.
Oral cavity probiotics and LLLT were the most effective treatment for improvement in quality of life. Further investigation on a larger group of patients is required.
本研究的目的是确定治疗灼口综合征最有效的治疗方案。
对单纯信息性治疗、维生素B注射、口腔益生菌和低强度激光治疗进行评估和比较。该研究纳入了新诊断为灼口综合征的患者，他们被随机分配到四个治疗组之一。主要结局是通过治疗前后自我感知的口腔健康影响程度量表-14（OHIP-14）生活质量问卷来确定患者生活质量的改善情况。次要结局是根据视觉模拟量表（VAS）从0到10的分级来确定黏膜症状强度。数据进行统计分析。
共有62名患者完成了研究。口腔益生菌和低强度激光治疗组的OHIP-14评分在治疗前后有统计学上的显著差异。接受口腔益生菌治疗的患者治疗前后OHIP评分之间的标准化效应量最大。
口腔益生菌和低强度激光治疗是改善生活质量最有效的治疗方法。需要对更多患者进行进一步研究。
