Sun Li-Li, Li Xu-Wen, Guo Yue-Wei
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Zhangjiang Hi-Tech Park, Shanghai 201203, China.
University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing 100049, China.
Mar Drugs. 2022 Mar 20;20(3):218. doi: 10.3390/md20030218.
Three complex polyoxygenated diterpenoids possessing uncommon tetradecahydro-2,13:6,9-diepoxybenzo[10]annulene scaffold, namely ximaoornatins A-C (-), one new eunicellin-type diterpene, litophynin K (), and a related known compound, litophynol B () were isolated from the South China Sea soft coral . The structures and absolute configurations of - were established by extensive spectroscopic analysis, X-ray diffraction analysis, and/or modified Mosher's method. A plausible biosynthetic relationship of and its potential precursor was proposed. In a bioassay, none of the isolated compounds showed obvious anti-inflammatory activity on LPS-induced TNF-α release in RAW264.7 macrophages and PTP1B inhibitory effects.
从中国南海软珊瑚中分离出三种具有罕见的十四氢-2,13:6,9-二环氧苯并[10]轮烯骨架的复杂多氧化二萜类化合物，即西毛奥纳汀A-C（-）、一种新的柳珊瑚素型二萜类化合物，石珊瑚素K（）和一种相关的已知化合物石珊瑚酚B（）。通过广泛的光谱分析、X射线衍射分析和/或改良的莫舍尔方法确定了-的结构和绝对构型。提出了与及其潜在前体的合理生物合成关系。在生物测定中，分离出的化合物均未对RAW264.7巨噬细胞中LPS诱导的TNF-α释放显示出明显的抗炎活性和PTP1B抑制作用。
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