State Key Laboratory of Drug Research, Shanghai Institute of MateriaMedica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Zhangjiang Hi-Tech Park, Shanghai 201203, China.
University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing 100049, China.
Mar Drugs. 2018 Mar 25;16(4):103. doi: 10.3390/md16040103.
A new prenyleudesmane type diterpene, sinupol (), and a new capnosane type diterpenoid, sinulacetate (), were isolated from the Xisha soft coral along with five known related diterpenes (- and ). Their structures, including absolute configurations, were determined by extensive spectroscopic analysis, the comparison of their NMR data with those of related compounds, and time-dependent density functional theory electronic circular dichroism (TDDFT ECD) calculations. Both new compounds ( and ) exhibited promising inhibitory activity against protein tyrosine phosphatase 1B (PTP1B), a potential drug target for the treatment of type II diabetes and obesity.
从西沙软珊瑚中分离得到了一种新的prenyleudesmane 型二萜化合物 sinupol（）和一种新的 capnosane 型二萜类化合物 sinulacetate（），以及五种已知的相关二萜类化合物 (- 和 )。通过广泛的光谱分析、与相关化合物的 NMR 数据比较以及时变密度泛函理论电子圆二色性（TDDFT ECD）计算，确定了它们的结构，包括绝对构型。这两个新化合物（和）对蛋白酪氨酸磷酸酶 1B（PTP1B）表现出了有希望的抑制活性，PTP1B 是治疗 II 型糖尿病和肥胖症的潜在药物靶点。
