State Key Laboratory of Drug Research , Shanghai Institute of Materia Medica, Chinese Academy of Sciences , 555 Zu Chong Zhi Road, Zhangjiang Hi-Tech Park , Shanghai 201203 , China.
University of Chinese Academy of Sciences , No. 19A Yuquan Road , Beijing 100049 , China.
Org Lett. 2019 Jul 19;21(14):5660-5664. doi: 10.1021/acs.orglett.9b01998. Epub 2019 Jul 3.
Two novel polyoxygenated diterpenoids, klyflaccilides A () and B (), featuring an uncommon 6/5/8/3 tetracyclic ring system, were isolated from the Hainan soft coral . Their structures were established by extensive spectroscopic analysis, X-ray diffraction analysis, and/or a quantum chemical computation method. A plausible biosynthetic relationship of and with their potential precursor was further proposed. Compounds and exhibited moderate anti-inflammatory activity by the inhibition of LPS-induced TNF-α protein release.
从海南软珊瑚 中分离得到两个新的多氧化二萜类化合物，klyflaccilides A()和 B()，具有不常见的 6/5/8/3 四环体系。通过广泛的光谱分析、X 射线衍射分析和/或量子化学计算方法确定了它们的结构。进一步提出了 和 与其潜在前体 的可能生物合成关系。化合物 和 通过抑制 LPS 诱导的 TNF-α 蛋白释放显示出适度的抗炎活性。
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