State Key Laboratory of Drug Research , Shanghai Institute of Materia Medica, Chinese Academy of Sciences , 555 Zu Chong Zhi Road, Zhangjiang Hi-Tech Park , Shanghai 201203 , China.
University of Chinese Academy of Sciences , No. 19A Yuquan Road , Beijing 100049 , China.
Org Lett. 2018 May 4;20(9):2637-2640. doi: 10.1021/acs.orglett.8b00842. Epub 2018 Apr 11.
Two novel nitrogenous diterpenoids, sarinfacetamides A (1) and B (2), featuring an uncommon tricyclo[6.3.1.0]dodecane scaffold, and a known related diterpene (3) were isolated from the South China Sea soft coral Sarcophyton infundibuliforme. Their structures, including the absolute configuration of 1, were established by extensive spectroscopic analysis and TDDFT-ECD calculation. Compounds 1 and 3 exhibited interesting promotion effects on the ConA-induced T lymphocyte proliferation. A plausible biosynthetic pathway for 1 and 2 was also proposed.
从南海软珊瑚 Sarcophyton infundibuliforme 中分离得到两个新型含氮二萜类化合物，sarinfacetamides A（1）和 B（2），具有不常见的三环[6.3.1.0]十二烷骨架，以及一个已知的相关二萜（3）。通过广泛的光谱分析和 TDDFT-ECD 计算确定了它们的结构，包括 1 的绝对构型。化合物 1 和 3 对 ConA 诱导的 T 淋巴细胞增殖具有有趣的促进作用。还提出了 1 和 2 的可能生物合成途径。
