Abunofal Omar, Mohan Chandra
Department of Biomedical Engineering, University of Houston, 3517 Cullen Blvd, Room 2004, Houston, TX 77204, USA.
Medicines (Basel). 2022 Mar 1;9(3):20. doi: 10.3390/medicines9030020.
Epigallocatechin-3-gallate (EGCG) is a polyphenol green tea catechin with potential health benefits and therapeutic effects in non-alcoholic fatty liver disease (NAFLD), a common liver disorder that adversely affects liver function and lipid metabolism. This systematic review surveyed the effects of EGCG or green tea extract (GTE) on NAFLD reported in studies involving rodent models or humans with a focus on clinicopathologic outcomes, lipid and carbohydrate metabolism, and inflammatory, oxidative stress, and liver injury markers. Articles involving clinical efficacy of EGCG/GTE on human subjects and rodent models were gathered by searching the PUBMED database and by referencing additional articles identified from other literature reviews. EGCG or GTE supplementation reduced body weight, adipose tissue deposits, and food intake. Mechanistically, the majority of these studies confirmed that EGCG or GTE supplementation plays a significant role in regulating lipid and glucose metabolism and expression of genes involved in lipid synthesis. Importantly, EGCG and GTE supplementation were shown to have beneficial effects on oxidative stress-related pathways that activate pro-inflammatory responses, leading to liver damage. In conclusion, green tea catechins are a potentially useful treatment option for NAFLD. More research is required to determine the ideal dosage, treatment duration, and most effective delivery method of EGCG or GTE, and to provide more definitive conclusions by performing large, randomized clinical trials.
表没食子儿茶素-3-没食子酸酯（EGCG）是一种多酚类绿茶儿茶素，对非酒精性脂肪性肝病（NAFLD）具有潜在的健康益处和治疗作用。NAFLD是一种常见的肝脏疾病，会对肝功能和脂质代谢产生不利影响。本系统评价调查了EGCG或绿茶提取物（GTE）对涉及啮齿动物模型或人类的研究中报告的NAFLD的影响，重点关注临床病理结果、脂质和碳水化合物代谢以及炎症、氧化应激和肝损伤标志物。通过搜索PUBMED数据库并参考从其他文献综述中确定的其他文章，收集了涉及EGCG/GTE对人类受试者和啮齿动物模型临床疗效的文章。补充EGCG或GTE可降低体重、脂肪组织沉积和食物摄入量。从机制上讲，这些研究中的大多数证实，补充EGCG或GTE在调节脂质和葡萄糖代谢以及参与脂质合成的基因表达方面发挥着重要作用。重要的是，EGCG和GTE补充剂对激活促炎反应导致肝损伤的氧化应激相关途径具有有益作用。总之，绿茶儿茶素是NAFLD一种潜在有用的治疗选择。需要更多的研究来确定EGCG或GTE的理想剂量、治疗持续时间和最有效的给药方法，并通过进行大型随机临床试验提供更明确的结论。
