Chou Yi-Hsin, Chen Yung-Tai, Chen Jinn-Yang, Tarng Der-Cherng, Lin Chih-Ching, Li Szu-Yuan
Division of Nephrology, Department of Medicine, Taipei Veterans General Hospital, Taipei 11217, Taiwan.
Department of Medicine, Taipei City Hospital Heping Fuyou Branch, Taipei 11217, Taiwan.
Membranes (Basel). 2022 Feb 28;12(3):276. doi: 10.3390/membranes12030276.
The peritoneal equilibration test (PET) is a semi-quantitative measurement that characterizes the rate of transfer of solutes and the water transfer rate across the peritoneum in patients treated with peritoneal dialysis (PD). The results of the PET are used to maximize daily peritoneal ultrafiltration and solute clearances. Previous studies have shown that high transport status is associated with ultrafiltration failure, malnutrition, and reduced survival; however, the way in which peritoneum transport characteristics affect peritonitis risk is unknown. In the current cohort study, we recruited 898 incident-PD patients and used intention-to-treat analysis to test if baseline PET affected the subsequent 3-year peritonitis rate. Among all recruited PD patients, 308 (34.2%) developed peritonitis within three years. Multivariate Cox regression analysis showed that the high-transport group has the greatest peritonitis risk (HR 1.98, 95% CI: 1.08-3.62) even after an adjustment for demographics, comorbid diseases, and biochemical measurements. We concluded that a baseline high peritoneal membrane transport rate is an independent risk factor for peritonitis in incident PD patients.
腹膜平衡试验（PET）是一种半定量测量方法，用于表征接受腹膜透析（PD）治疗的患者腹膜溶质转运速率和水转运速率。PET结果用于使每日腹膜超滤和溶质清除最大化。先前的研究表明，高转运状态与超滤失败、营养不良和生存率降低有关；然而，腹膜转运特征影响腹膜炎风险的方式尚不清楚。在当前的队列研究中，我们招募了898例新发PD患者，并采用意向性分析来检验基线PET是否会影响随后3年的腹膜炎发生率。在所有招募的PD患者中，308例（34.2%）在3年内发生了腹膜炎。多变量Cox回归分析表明，即使在对人口统计学、合并疾病和生化指标进行调整后，高转运组的腹膜炎风险最高（HR 1.98，95%CI：1.08-3.62）。我们得出结论，基线腹膜转运速率高是新发PD患者发生腹膜炎的独立危险因素。
