Caudill Jennifer, Thomas Jean E, Burkhart Craig G
University of Toledo College of Medicine, Toledo, OH, USA.
Mercy St. Vincent Medical Center, Toledo, OH, USA.
Int J Dermatol. 2023 Apr;62(4):483-486. doi: 10.1111/ijd.16164. Epub 2022 Mar 24.
Cutaneous squamous cell carcinoma (cSCC) is the second most common nonmelanoma skin cancer, accounting for 20% of all skin cancers. The risk of the disease continues to rise annually with an estimated 50-200% increase in incidence within the last three decades. Although cSCC is one of the most common skin cancers, reported having 1 million cases per year in the United States, there is inconsistency with its reported metastatic rate. Research exploring cSCC metastasis found an overall rate of 1.2-5% but this range varies, and some dermatologists are finding cSCC's ability to spread more worrisome. This allows for clinical variation in the appropriate treatments and follow-up guidelines when diagnosing a patient with cSCC. Poor prognosis in patients with a high metastatic potential makes cSCC clinically problematic. Clinician emphasis should be put on risk factors, anatomical site, tumor presentation, and histological features when evaluating cSCC's metastatic potential. In this review, specific skin conditions that predispose to cSCC and discrepancies in its reported metastatic potential will be discussed.
皮肤鳞状细胞癌（cSCC）是第二常见的非黑色素瘤皮肤癌，占所有皮肤癌的20%。该疾病的风险每年持续上升，在过去三十年中发病率估计增加了50%-200%。尽管cSCC是最常见的皮肤癌之一，在美国每年报告有100万例病例，但其报告的转移率存在不一致性。探索cSCC转移的研究发现总体转移率为1.2%-5%，但这个范围有所不同，一些皮肤科医生发现cSCC的扩散能力更令人担忧。这使得在诊断cSCC患者时，适当的治疗和随访指南存在临床差异。具有高转移潜能的患者预后不良，这使得cSCC在临床上成为一个问题。在评估cSCC的转移潜能时，临床医生应重点关注风险因素、解剖部位、肿瘤表现和组织学特征。在这篇综述中，将讨论易患cSCC的特定皮肤状况及其报告的转移潜能差异。
