Zhang Yan, Sun Yuanchao, Dong Xia, Wang Qiang-Song, Zhu Dunwan, Mei Lin, Yan Husheng, Lv Feng
Tianjin Key Laboratory of Biomedical Materials, Key Laboratory of Biomaterials and Nanotechnology for Cancer Immunotherapy, Institute of Biomedical Engineering, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300192, People's Republic of China.
Key Laboratory of Functional Polymer Materials (Ministry of Education), College of Chemistry, Nankai University, Tianjin 300071, People's Republic of China.
ACS Nano. 2022 Apr 26;16(4):6359-6371. doi: 10.1021/acsnano.2c00453. Epub 2022 Mar 24.
Controllable and visible delivery of therapeutic agents is critical for tumor precise therapy. Tumor targeting and deep penetration of therapeutic agents are still challenging issues for controllable delivery. Visible drug delivery with imaging navigation can optimize the treatment window for personalized medicine. Herein, a biomimetic platelet intelligent vehicle with navigation (IRDNP-PLT) was developed to achieve controllable and visible delivery with a navigation system, a driving system, and a loading system. The platelets acted as engines and drug repositories to exert the target driving and delivery functions. The fluorescent photothermal agent IR-820 was introduced in the platform to offer an imaging navigation for the intelligent platelet vehicle in addition to photothermal therapy. The nanodrug-loaded platelets enabled efficient drug loading and controlled release of the therapeutic payload by encapsulating photothermal-/pH-sensitive chemotherapeutic nanoparticles (PDA@Dox NPs). In experiments on 4T1 tumor-bearing mice models, IRDNP-PLT performed well in tumor targeting and showed excellent therapeutic efficacy and tumor recurrence prevention ability. The intelligent platelet vehicle achieved the functions of tumor targeting and deep penetration, fluorescence imaging guidance, photocontrolled drug release, and chemo-photothermal combination therapy, suggesting the advancement for tumor precise delivery and efficient therapy.
治疗剂的可控且可视化递送对于肿瘤精确治疗至关重要。治疗剂的肿瘤靶向和深度渗透仍然是可控递送面临的挑战性问题。具有成像导航的可视化药物递送可以优化个性化医疗的治疗窗口。在此，开发了一种具有导航功能的仿生血小板智能载体（IRDNP-PLT），以通过导航系统、驱动系统和负载系统实现可控且可视化的递送。血小板充当引擎和药物库，发挥靶向驱动和递送功能。荧光光热剂IR-820被引入该平台，除了光热疗法外，还为智能血小板载体提供成像导航。负载纳米药物的血小板通过包裹光热/ pH敏感化疗纳米颗粒（PDA@Dox NPs）实现了治疗有效载荷的高效负载和控释。在4T1荷瘤小鼠模型实验中，IRDNP-PLT在肿瘤靶向方面表现良好，并显示出优异的治疗效果和肿瘤复发预防能力。该智能血小板载体实现了肿瘤靶向和深度渗透、荧光成像引导、光控药物释放以及化疗-光热联合治疗等功能，表明其在肿瘤精确递送和高效治疗方面取得了进展。
