Xie Lijuan, Gan Fengxu, Hu Yun, Zheng Yibin, Lan Junshan, Liu Yuting, Zhou Xiaofang, Zheng Jianyu, Zhou Xing, Lou Jie
School of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing 400054, China.
Chongqing Key Laboratory of Medicinal Chemistry and Molecular Pharmacology, Chongqing University of Technology, Chongqing 400054, China.
J Funct Biomater. 2025 Jan 6;16(1):15. doi: 10.3390/jfb16010015.
Biomimetic nanodrug delivery systems based on cell membranes have emerged as a promising approach for targeted cancer therapy due to their biocompatibility and low immunogenicity. Among them, platelet-mediated systems are particularly noteworthy for their innate tumor-homing and cancer cell interaction capabilities. These systems utilize nanoparticles shielded and directed by platelet membrane coatings for efficient drug delivery. This review highlights the role of platelets in cancer therapy, summarizes the advancements in platelet-based drug delivery systems, and discusses their integration with other cancer treatments. Additionally, it addresses the limitations and challenges of platelet-mediated drug delivery, offering insights into future developments in this innovative field.
基于细胞膜的仿生纳米药物递送系统因其生物相容性和低免疫原性，已成为靶向癌症治疗的一种有前景的方法。其中，血小板介导的系统因其固有的肿瘤归巢和癌细胞相互作用能力而特别值得关注。这些系统利用由血小板膜涂层屏蔽和导向的纳米颗粒进行高效药物递送。本文综述强调了血小板在癌症治疗中的作用，总结了基于血小板的药物递送系统的进展，并讨论了它们与其他癌症治疗方法的整合。此外，还阐述了血小板介导的药物递送的局限性和挑战，为这一创新领域的未来发展提供了见解。
