健康亚洲人“正常肝脏”的 T1 弛豫时间：在 3T 下使用 MOLLI 和 B 校正 VFA 方法进行测量。
Liver T1 relaxation time of the 'normal liver' in healthy Asians: measurement with MOLLI and B-corrected VFA methods at 3T.
机构信息
Department of Radiology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Shandong, China.
Shandong Provincial Hospital Affiliated to Shandong First Medical University, Shandong University, Shandong, China.
出版信息
Br J Radiol. 2022 May 1;95(1133):20211008. doi: 10.1259/bjr.20211008. Epub 2022 Mar 24.
OBJECTIVES
Liver T1 is a potential magnetic resonance imaging biomarker for liver diseases. This study aimed to determine the T1 relaxation time of the normal liver (PDFF<5%) in healthy Asian volunteers using modified look-locker inversion recovery (MOLLI) and B inhomogeneity-corrected variable flip angle (B-corrected VFA).
METHODS
60 healthy Asian volunteers without focal or diffuse liver disease underwent a liver scan at 3T magnetic resonance. Proton density fat fraction (PDFF) and liver stiffness measurements were applied for the quantification of liver fat and fibrosis. T1 mapping was performed with MOLLI and B-corrected VFA sequences. Bland-Altman, linear regression, Student t-test, and one-way analysis of variance were used for statistical analysis.
RESULTS
The mean T1 relaxation times of the whole liver were 901 ± 34 ms by MOLLI, and 948 ± 29 ms by B-corrected VFA in healthy volunteers. There was a strong correlation ( = 0.86, < 0.0001) for liver T1 between two T1 mapping methods. There were significant differences between the right and left lobes in liver T1 relaxation times using both methods ( < 0.05). Gender and Asian ethnic disparities had no impact on liver T1 relaxation times.
CONCLUSION
T1 relaxation times of the normal liver (PDFF<5%) in healthy volunteers were established by MOLLI and B-corrected VFA T1 mapping methods at 3T. It may provide suitable and robust baseline values for the assessment of liver diseases.
ADVANCES IN KNOWLEDGE
Gender and Asian ethnic disparities do not impact liver T1 relaxation time measurements.
目的
肝脏 T1 弛豫时间是一种潜在的磁共振成像生物标志物，可用于诊断肝脏疾病。本研究旨在采用改良 Look-Locker 反转恢复（MOLLI）和 B 不均匀校正可变翻转角（B-corrected VFA）序列测量健康亚洲志愿者正常肝脏（PDFF<5%）的 T1 弛豫时间。
方法
本研究纳入了 60 名无局灶性或弥漫性肝脏疾病的健康亚洲志愿者，在 3T 磁共振仪上进行了肝脏扫描。质子密度脂肪分数（PDFF）和肝脏硬度测量用于量化肝脏脂肪和纤维化。采用 MOLLI 和 B-corrected VFA 序列进行 T1 mapping。采用 Bland-Altman 分析、线性回归、Student t 检验和单因素方差分析进行统计学分析。
结果
MOLLI 测量的健康志愿者全肝 T1 弛豫时间平均值为 901±34ms，B-corrected VFA 为 948±29ms，两种 T1 映射方法之间存在很强的相关性（ = 0.86， < 0.0001）。两种方法均显示肝脏 T1 在左右叶之间存在显著差异（ < 0.05）。性别和亚洲种族差异对肝脏 T1 弛豫时间无影响。
结论
本研究采用 MOLLI 和 B-corrected VFA T1 映射方法在 3T 测量了健康志愿者正常肝脏（PDFF<5%）的 T1 弛豫时间。这些结果可为肝脏疾病的评估提供合适且稳健的基线值。
知识进展
性别和亚洲种族差异不影响肝脏 T1 弛豫时间的测量。
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