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应用自由呼吸 MOLLI 序列对儿童和青年进行肝脏 T1 mapping 的验证和可行性研究。

Validation and feasibility of liver T1 mapping using free breathing MOLLI sequence in children and young adults.

机构信息

Department of Radiology, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, Seoul, 03080, Republic of Korea.

Department of Radiology, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul, 03080, Republic of Korea.

出版信息

Sci Rep. 2020 Oct 27;10(1):18390. doi: 10.1038/s41598-020-74717-2.

DOI:10.1038/s41598-020-74717-2
PMID:33110134
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7591907/
Abstract

We investigated the feasibility of free-breathing modified Look-Locker inversion recovery (MOLLI) sequence for measuring hepatic T1 values in children and young adults. To investigate the accuracy and the reproducibility of the T1 maps, a phantom study was performed with 12 different gadoterate meglumine concentrations and the T1 relaxation times of phantoms measured with the MOLLI sequence were compared against those measured with three different sequences: spin-echo inversion recovery, variable flip angle (VFA), and VFA with B1 correction. To evaluate the feasibility of free-breathing MOLLI sequence, hepatic T1 relaxation times obtained by free-breathing and breath-hold technique in twenty patients were compared. The phantom study revealed the excellent accuracy and reproducibility of MOLLI. In twenty patients, the mean value of hepatic T1 values obtained by free-breathing (606.7 ± 64.5 ms) and breath-hold (609.8 ± 64.0 ms) techniques showed no significant difference (p > 0.05). The Bland-Altman plot between the free-breathing and breath-hold revealed that the mean difference of T1 values was - 3.0 ms (- 0.5%). Therefore, T1 relaxation times obtained by MOLLI were comparable to the values obtained using the standard inversion recovery method. The hepatic T1 relaxation times measured by MOLLI technique with free-breathing were comparable to those obtained with breath-hold in children and young adults.

摘要

我们研究了自由呼吸的改良 Look-Locker 反转恢复（MOLLI）序列测量儿童和年轻成人肝脏 T1 值的可行性。为了研究 T1 图的准确性和可重复性，我们进行了一项包含 12 种不同钆喷替酸葡甲胺浓度的体模研究，并将 MOLLI 序列测量的体模 T1 弛豫时间与三种不同序列（自旋回波反转恢复、可变翻转角（VFA）和带 B1 校正的 VFA）测量的 T1 弛豫时间进行了比较。为了评估自由呼吸 MOLLI 序列的可行性，我们比较了二十名患者通过自由呼吸和屏气技术获得的肝脏 T1 弛豫时间。体模研究显示 MOLLI 具有出色的准确性和可重复性。在二十名患者中，自由呼吸（606.7 ± 64.5ms）和屏气（609.8 ± 64.0ms）技术获得的肝脏 T1 值的平均值无显著差异（p＞0.05）。自由呼吸和屏气之间的 Bland-Altman 图显示 T1 值的平均差异为 -3.0ms（-0.5%）。因此，MOLLI 获得的 T1 弛豫时间与使用标准反转恢复方法获得的 T1 值相当。在儿童和年轻成人中，MOLLI 技术通过自由呼吸测量的肝脏 T1 弛豫时间与通过屏气获得的 T1 弛豫时间相当。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/624b/7591907/adaa965a15a9/41598_2020_74717_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/624b/7591907/d4a59bf1d3d8/41598_2020_74717_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/624b/7591907/90c0892d561a/41598_2020_74717_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/624b/7591907/58e05da00879/41598_2020_74717_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/624b/7591907/8ffe2dddf9dd/41598_2020_74717_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/624b/7591907/7c56afcb1ca5/41598_2020_74717_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/624b/7591907/7eb5b565c8ba/41598_2020_74717_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/624b/7591907/adaa965a15a9/41598_2020_74717_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/624b/7591907/d4a59bf1d3d8/41598_2020_74717_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/624b/7591907/90c0892d561a/41598_2020_74717_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/624b/7591907/58e05da00879/41598_2020_74717_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/624b/7591907/8ffe2dddf9dd/41598_2020_74717_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/624b/7591907/7c56afcb1ca5/41598_2020_74717_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/624b/7591907/7eb5b565c8ba/41598_2020_74717_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/624b/7591907/adaa965a15a9/41598_2020_74717_Fig7_HTML.jpg

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