新英格兰居民中宫本疏螺旋体、伯氏疏螺旋体和微小巴贝斯虫感染的频率及地理分布

Frequency and Geographic Distribution of Borrelia miyamotoi, Borrelia burgdorferi, and Babesia microti Infections in New England Residents.

作者信息

Johnston Demerise, Kelly Jill R, Ledizet Michel, Lavoie Nathalie, Smith Robert P, Parsonnet Jeffrey, Schwab Jonathan, Stratidis John, Espich Scott, Lee Giyoung, Maciejewski Kaitlin R, Deng Yanhong, Majam Victoria, Zheng Hong, Bonkoungou Sougr-Nooma, Stevens June, Kumar Sanjai, Krause Peter J

机构信息

Yale School of Public Health, Department of Epidemiology of Microbial Diseases and Yale School of Medicine, New Haven, Connecticut, USA.

US Food and Drug Administration, Laboratory of Emerging Pathogens, Silver Spring, Maryland, USA.

出版信息

Clin Infect Dis. 2022 Mar 23. doi: 10.1093/cid/ciac107.

DOI:10.1093/cid/ciac107

PMID:35325084

Abstract

BACKGROUND

Borrelia miyamotoi is a relapsing fever spirochete that relatively recently has been reported to infect humans. It causes an acute undifferentiated febrile illness that can include meningoencephalitis and relapsing fever. Like Borrelia burgdorferi, it is transmitted by Ixodes scapularis ticks in the northeastern United States and by Ixodes pacificus ticks in the western United States. Despite reports of clinical cases from North America, Europe, and Asia, the prevalence, geographic range, and pattern of expansion of human B. miyamotoi infection are uncertain. To better understand these characteristics of B. miyamotoi in relation to other tickborne infections, we carried out a cross-sectional seroprevalence study across New England that surveyed B. miyamotoi, B. burgdorferi, and Babesia microti infections.

METHODS

We measured specific antibodies against B. miyamotoi, B. burgdorferi, and B. microti among individuals living in 5 New England states in 2018.

RESULTS

Analysis of 1153 serum samples collected at 11 catchment sites showed that the average seroprevalence for B. miyamotoi was 2.8% (range, 0.6%-5.2%), which was less than that of B. burgdorferi (11.0%; range, 6.8%-15.6%) and B. microti (10.0%; range, 6.5%-13.6%). Antibody screening within county residence in New England showed varying levels of seroprevalence for these pathogens but did not reveal a vectoral geographical pattern of distribution.

CONCLUSIONS

Human infections caused by B. miyamotoi, B. burgdorferi, and B. microti are widespread with varying prevalence throughout New England.

摘要

背景

宫本疏螺旋体是一种回归热螺旋体，相对较新地被报道可感染人类。它会引发一种急性未分化发热性疾病，可能包括脑膜脑炎和回归热。与伯氏疏螺旋体一样，在美国东北部它由肩突硬蜱传播，在美国西部由太平洋硬蜱传播。尽管北美、欧洲和亚洲都有临床病例报告，但人类宫本疏螺旋体感染的患病率、地理范围和传播模式仍不确定。为了更好地了解宫本疏螺旋体相对于其他蜱传感染的这些特征，我们在新英格兰地区开展了一项横断面血清流行率研究，调查宫本疏螺旋体、伯氏疏螺旋体和微小巴贝斯虫感染情况。

方法

我们在2018年对居住在新英格兰5个州的个体检测了针对宫本疏螺旋体、伯氏疏螺旋体和微小巴贝斯虫的特异性抗体。

结果

对在11个集水区采集的1153份血清样本进行分析显示，宫本疏螺旋体的平均血清流行率为2.8%（范围为0.6% - 5.2%），低于伯氏疏螺旋体（11.0%；范围为6.8% - 15.6%）和微小巴贝斯虫（10.0%；范围为6.5% - 13.6%）。在新英格兰按县居住地进行的抗体筛查显示这些病原体的血清流行率水平各不相同，但未揭示出媒介传播的地理分布模式。