Faculty of Science, Biology Centre CAS, Institute of Parasitology and University of South Bohemia, České Budějovice, Czech Republic.
J Eukaryot Microbiol. 2022 Nov;69(6):e12911. doi: 10.1111/jeu.12911. Epub 2022 May 3.
The unicellular parasite Trypanosoma brucei has a digenetic life cycle that alternates between a mammalian host and an insect vector. During programmed development, this extracellular parasite encounters strikingly different environments that determine its energy metabolism. Functioning as a bioenergetic, biosynthetic, and signaling center, the single mitochondrion of T. brucei is drastically remodeled to support the dynamic cellular demands of the parasite. This manuscript will provide an up-to-date overview of how the distinct T. brucei developmental stages differ in their mitochondrial metabolic and bioenergetic pathways, with a focus on the electron transport chain, proline oxidation, TCA cycle, acetate production, and ATP generation. Although mitochondrial metabolic rewiring has always been simply viewed as a consequence of the differentiation process, the possibility that certain mitochondrial activities reinforce parasite differentiation will be explored.
单细胞寄生虫布氏锥虫具有双核生命周期，在哺乳动物宿主和昆虫媒介之间交替。在程序性发育过程中，这种细胞外寄生虫遇到了截然不同的环境，这些环境决定了它的能量代谢。作为生物能量学、生物合成和信号中心，布氏锥虫的单个线粒体经历了剧烈的重塑，以支持寄生虫的动态细胞需求。本文将提供一个最新的概述，说明不同的布氏锥虫发育阶段在其线粒体代谢和生物能量途径上的差异，重点关注电子传递链、脯氨酸氧化、三羧酸循环、乙酸盐生成和 ATP 生成。尽管线粒体代谢的重排一直被简单地视为分化过程的结果，但某些线粒体活动是否会增强寄生虫分化的可能性将被探讨。
