Lee Kayoung
Department of Family Medicine, Busan Paik Hospital, Inje University College of Medicine, Busan, Korea.
J Bone Metab. 2022 Feb;29(1):23-33. doi: 10.11005/jbm.2022.29.1.23. Epub 2022 Feb 28.
This study aimed to determine whether food security moderates the relationship of skeletal muscle mass with metabolic syndrome (MetS) and insulin resistance (IR).
This study analyzed the data of 10,680 adults using the Korea National Health and Nutrition Examination Survey from 2008 to 2011. The food security reported by households, appendicular skeletal muscle mass (ASM) divided by body mass index (BMI) (ASM/BMI), weight (ASM/weight), or height squared (ASM/height2) as muscle mass indicators, MetS (defined as presence of at least 3 components of MetS), and IR (defined as sex-specific highest quintile of homeostatic model assessment for IR) were assessed. The association between the muscle mass indicators and food security as well as their interaction with MetS and IR was analyzed for all participants and each sex using complex sample logistic regression and general linear model analyses.
When the ASM/BMI increased by 0.1 kg/BMI, the odds for MetS and IR decreased by 36% and 29%, respectively, after adjusting for age, sex, education, economic level, smoking, alcohol consumption, physical activity, chronic diseases, and intake of fats and protein. There was a significant interaction between ASM/BMI and food security in their relationship with MetS and its components. In the low food security group, the inverse relationship of ASM/BMI with MetS and IR was stronger than in the food security group. These findings were more pronounced in men than in women, and similar findings were observed in the association with ASM/weight.
The associations of skeletal muscle mass with MetS and IR may be influenced by household food security in Korean adults.
本研究旨在确定粮食安全是否会调节骨骼肌质量与代谢综合征（MetS）及胰岛素抵抗（IR）之间的关系。
本研究分析了2008年至2011年韩国国家健康与营养检查调查中10680名成年人的数据。评估了家庭报告的粮食安全情况、作为肌肉质量指标的四肢骨骼肌质量（ASM）除以体重指数（BMI）（ASM/BMI）、体重（ASM/体重）或身高平方（ASM/身高²）、代谢综合征（定义为存在至少3种代谢综合征成分）和胰岛素抵抗（定义为胰岛素抵抗的稳态模型评估中按性别划分的最高五分位数）。使用复杂样本逻辑回归和一般线性模型分析，对所有参与者和各性别分析了肌肉质量指标与粮食安全之间的关联及其与代谢综合征和胰岛素抵抗的相互作用。
在调整年龄、性别、教育程度、经济水平、吸烟、饮酒、身体活动、慢性病以及脂肪和蛋白质摄入量后，当ASM/BMI每增加0.1kg/BMI时，代谢综合征和胰岛素抵抗的比值分别降低36%和29%。ASM/BMI与粮食安全在它们与代谢综合征及其成分的关系中存在显著的相互作用。在粮食安全水平低的组中，ASM/BMI与代谢综合征和胰岛素抵抗的负相关关系比粮食安全组更强。这些发现在男性中比在女性中更明显，并且在与ASM/体重的关联中也观察到了类似的结果。
韩国成年人中，骨骼肌质量与代谢综合征和胰岛素抵抗之间的关联可能受家庭粮食安全的影响。
