Glaucoma Services, Director; B B Eye Foundation, Kolkata, West Bengal, India.
Comprehensive Ophthalmology; B B Eye Foundation, Kolkata, West Bengal, India.
Indian J Ophthalmol. 2022 Apr;70(4):1248-1252. doi: 10.4103/ijo.IJO_2027_21.
To comparatively evaluate in Indian eyes with coexisting cataract and primary open-angle glaucoma the outcome of mitomycin C (MMC) and Ologen implant as adjunctives in combined phacoemulsification with trabeculectomy.
Eyes with primary open-angle glaucoma that underwent trabeculectomy and phacoemulsification with IOL implantation with either MMC application or Ologen implant between June 2019 and February 2020 were followed up for 12 months. Thirty-four eyes of 34 participants were studied. The primary outcome was intraocular pressure (IOP), and the secondary outcomes were the number of ocular hypotensives, best distance visual acuity (BDVA), and bleb morphology.
In 16 eyes treated with MMC and 18 eyes treated with Ologen implant, it was observed that the mean postoperative IOP (14.62 ± 2.89 mm Hg with MMC and 14.56 ± 4.14 mm Hg with Ologen implant) was not significantly different in both groups (P = 0.47). Number of ocular hypotensives and BDVA were also comparable between the two groups. However, bleb morphology was better with Ologen implantation. One eye in the MMC group developed hypotony which was conservatively managed.
MMC and Ologen are both effective adjunctives in combined phaco-trabeculectomy. However, the Ologen implant provides better bleb health and safety.
在伴有白内障和原发性开角型青光眼的印度人群中，比较丝裂霉素 C（MMC）和 Ologen 植入物作为超声乳化白内障吸除术联合小梁切除术的辅助治疗的效果。
2019 年 6 月至 2020 年 2 月期间，对接受小梁切除术和超声乳化白内障吸除术联合人工晶状体植入术的原发性开角型青光眼患者进行研究，术中分别应用 MMC 或 Ologen 植入物。共 34 只眼，34 名患者纳入研究。主要观察指标为眼内压（IOP），次要观察指标包括降压药物的使用数量、最佳距离视力（BDVA）和滤过泡形态。
在接受 MMC 治疗的 16 只眼中和接受 Ologen 植入物治疗的 18 只眼中，术后平均 IOP（MMC 组为 14.62±2.89mmHg，Ologen 组为 14.56±4.14mmHg）在两组间无显著差异（P=0.47）。两组间降压药物的使用数量和 BDVA 也无显著差异。然而，Ologen 植入物组的滤过泡形态更好。MMC 组中有 1 只眼发生低眼压，经保守治疗后缓解。
MMC 和 Ologen 均为超声乳化白内障吸除术联合小梁切除术的有效辅助治疗方法。然而，Ologen 植入物可提供更好的滤过泡健康和安全性。
