Fehrenbach Michael Karl, Dietel Eric, Wende Tim, Kasper Johannes, Sander Caroline, Wilhelmy Florian, Quaeschling Ulf, Meixensberger Juergen, Nestler Ulf
Department of Neurosurgery, University Hospital Leipzig, 04103 Leipzig, Germany.
Institute of Neuroradiology, University Hospital Leipzig, 04103 Leipzig, Germany.
Brain Sci. 2022 Feb 28;12(3):330. doi: 10.3390/brainsci12030330.
While cavernous carotid aneurysms can cause neurological symptoms, their often-uneventful natural course and the increasing options of intravascular aneurysm closure call for educated decision-making. However, evidence-based guidelines are missing. Here, we report 64 patients with cavernous carotid aneurysms, their respective therapeutic strategies, and follow-up.
We included all patients with cavernous carotid aneurysms who presented to our clinic between 2014 and 2020 and recorded comorbidities (elevated blood pressure, diabetes mellitus, and nicotine consumption), PHASES score, aneurysm site, size and shape, therapeutic strategy, neurological deficits, and clinical follow-up.
The mean age of the 64 patients (86% female) was 53 years, the mean follow-up time was 3.8 years. A total of 22 patients suffered from cranial nerve deficit. Of these patients, 50% showed a relief of symptoms regardless of the therapy regime. We found no significant correlations between aneurysm size or PHASES score and the occurrence of neurological symptoms.
If aneurysm specific symptoms persist over a longer period of time, relief is difficult to achieve despite aneurysm treatment. Patients should be advised by experts in neurovascular centers, weighing the possibility of an uneventful course against the risks of treatment. In this regard, more detailed prospective data is needed to improve individual patient counseling.
虽然海绵窦段颈动脉瘤可引起神经症状,但其通常平稳的自然病程以及血管内动脉瘤闭塞治疗选择的增加,需要进行明智的决策。然而,目前尚缺乏循证指南。在此,我们报告64例海绵窦段颈动脉瘤患者、各自的治疗策略及随访情况。
我们纳入了2014年至2020年间在我院就诊的所有海绵窦段颈动脉瘤患者,并记录其合并症(高血压、糖尿病和吸烟情况)、PHASES评分、动脉瘤部位、大小和形态、治疗策略、神经功能缺损及临床随访情况。
64例患者(86%为女性)的平均年龄为53岁,平均随访时间为3.8年。共有22例患者存在颅神经缺损。在这些患者中,无论治疗方案如何,50%的患者症状得到缓解。我们发现动脉瘤大小或PHASES评分与神经症状的发生之间无显著相关性。
如果动脉瘤特定症状持续较长时间,即使进行动脉瘤治疗也难以缓解症状。应建议患者前往神经血管中心,由专家权衡平稳病程的可能性与治疗风险。在这方面,需要更详细的前瞻性数据以改善对个体患者的咨询。