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（±）-儿茶素-A：基于质谱法探索与铁和亚铁形成配位络合物的情况

(±)-Catechin-A Mass-Spectrometry-Based Exploration Coordination Complex Formation with Fe and Fe.

作者信息

Kubicova Lenka, Bachmann Gert, Weckwerth Wolfram, Chobot Vladimir

机构信息

Division of Molecular Systems Biology, Department of Functional and Evolutionary Ecology, Faculty of Life Sciences, University of Vienna, Djerassiplatz 1, A-1030 Vienna, Austria.

Vienna Metabolomics Center (VIME), University of Vienna, Djerassiplatz 1, A-1030 Vienna, Austria.

出版信息

Cells. 2022 Mar 11;11(6):958. doi: 10.3390/cells11060958.

DOI:10.3390/cells11060958
PMID:35326409
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8946835/
Abstract

Catechin is an extensively investigated plant flavan-3-ol with a beneficial impact on human health that is often associated with antioxidant activities and iron coordination complex formation. The aim of this study was to explore these properties with Fe and Fe using a combination of nanoelectrospray-mass spectrometry, differential pulse voltammetry, site-specific deoxyribose degradation assay, Fe autoxidation assay, and brine shrimp mortality assay. Catechin primarily favored coordination complex formation with Fe ions of the stoichiometry catechin:Fe in the ratio of 1:1 or 2:1. In the detected Fe-catechin coordination complexes, Fe prevailed. Differential pulse voltammetry, the site-specific deoxyribose degradation, and Fe autoxidation assays proved that coordination complex formation affected catechin's antioxidant effects. In situ formed Fe-catechin coordination complexes showed no toxic activities in the brine shrimp mortality assay. In summary, catechin has properties for the possible treatment of pathological processes associated with ageing and degeneration, such as Alzheimer's and Parkinson's diseases.

摘要

儿茶素是一种经过广泛研究的植物黄烷-3-醇，对人体健康有益，常与抗氧化活性和铁配位络合物的形成有关。本研究的目的是结合纳米电喷雾质谱、差分脉冲伏安法、位点特异性脱氧核糖降解试验、铁自氧化试验和卤虫致死试验，探讨儿茶素与铁（Fe）和亚铁（Fe）的这些性质。儿茶素主要倾向于与化学计量比为儿茶素:Fe为1:1或2:1的铁离子形成配位络合物。在检测到的铁-儿茶素配位络合物中，铁占主导。差分脉冲伏安法、位点特异性脱氧核糖降解试验和铁自氧化试验证明，配位络合物的形成影响了儿茶素的抗氧化作用。原位形成的铁-儿茶素配位络合物在卤虫致死试验中未显示出毒性活性。总之，儿茶素具有治疗与衰老和退化相关的病理过程（如阿尔茨海默病和帕金森病）的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e6d/8946835/d69ca685ada5/cells-11-00958-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e6d/8946835/9b6dd9c3deba/cells-11-00958-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e6d/8946835/0f1da117b1fd/cells-11-00958-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e6d/8946835/60db5280da69/cells-11-00958-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e6d/8946835/e166e8376aa6/cells-11-00958-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e6d/8946835/459237c6b7f5/cells-11-00958-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e6d/8946835/482645a3e472/cells-11-00958-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e6d/8946835/a58f28ebdc22/cells-11-00958-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e6d/8946835/d69ca685ada5/cells-11-00958-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e6d/8946835/9b6dd9c3deba/cells-11-00958-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e6d/8946835/0f1da117b1fd/cells-11-00958-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e6d/8946835/60db5280da69/cells-11-00958-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e6d/8946835/e166e8376aa6/cells-11-00958-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e6d/8946835/459237c6b7f5/cells-11-00958-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e6d/8946835/482645a3e472/cells-11-00958-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e6d/8946835/a58f28ebdc22/cells-11-00958-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e6d/8946835/d69ca685ada5/cells-11-00958-g008.jpg

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