Center of Excellence for Aging and Brain Repair, University of South Florida Morsani College of Medicine, 12901 Bruce B Downs Blvd, Tampa, FL 33612, USA.
Universidad Peruana de Ciencias Aplicadas, Prolongación Primavera 2390, Lima 15023, Peru.
Cells. 2022 Mar 17;11(6):1013. doi: 10.3390/cells11061013.
Ischemic brain injury represents a major cause of death worldwide with limited treatment options with a narrow therapeutic window. Accordingly, novel treatments that extend the treatment from the early neuroprotective stage to the late regenerative phase may accommodate a much larger number of stroke patients. To this end, stem cell-based regenerative therapies may address this unmet clinical need. Several stem cell therapies have been tested as potentially exhibiting the capacity to regenerate the stroke brain. Based on the long track record and safety profile of transplantable stem cells for hematologic diseases, bone marrow-derived mesenchymal stromal cells or mesenchymal stromal cells have been widely tested in stroke animal models and have reached clinical trials. However, despite the translational promise of MSCs, probing cell function remains to be fully elucidated. Recognizing the multi-pronged cell death and survival processes that accompany stroke, here we review the literature on MSC definition, characterization, and mechanism of action in an effort to gain a better understanding towards optimizing its applications and functional outcomes in stroke.
缺血性脑损伤是全球范围内主要的死亡原因，治疗选择有限，治疗窗口狭窄。因此，新型治疗方法将治疗从早期神经保护阶段扩展到晚期再生阶段，可能会适应更多的中风患者。为此，基于干细胞的再生疗法可能可以满足这一未满足的临床需求。已经有几种干细胞疗法被测试为具有再生中风大脑的潜力。基于用于血液疾病的可移植干细胞的长期记录和安全性概况，骨髓来源的间充质基质细胞或间充质基质细胞已在中风动物模型中广泛测试，并已进入临床试验。然而，尽管间充质干细胞具有转化的潜力，但探测细胞功能仍有待充分阐明。认识到中风伴随的多方面细胞死亡和存活过程，我们在这里回顾了间充质干细胞的定义、特征和作用机制的文献，以努力更好地理解如何优化其在中风中的应用和功能结果。
